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Item 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

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Item 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

(a)(1) and (2) Financial Statements and Financial Statement Schedule

The financial statements and financial statement schedule required by this Item are included as a separate section in this annual report on Form 10-K beginning on page F-1.

Page
Report of Independent Registered Public Accounting Firm (PCAOB ID: 00042)1
Audited Consolidated Financial Statements of Alexandria Real Estate Equities, Inc.:
Consolidated Balance Sheets as of December 31, 2021 and 20203
Consolidated Financial Statements for the Years Ended December 31, 2021, 2020, and 2019:
Consolidated Statements of Operations4
Consolidated Statements of Comprehensive Income5
Consolidated Statements of Changes in Stockholders’ Equity and Noncontrolling Interests6
Consolidated Statements of Cash Flows8
Notes to Consolidated Financial Statements10
Schedule III – Consolidated Financial Statement Schedule of Real Estate and Accumulated Depreciation52

(a)(3) Exhibits

Exhibit NumberExhibit TitleIncorporated by Reference to:Date Filed
3.1*Articles of Amendment and Restatement of the CompanyForm 10-QAugust 14, 1997
3.2*Certificate of Correction of the CompanyForm 10-QAugust 14, 1997
3.3*Articles of Amendment of the Company, dated May 10, 2017Form 8-KMay 12, 2017
3.4*Articles Supplementary, dated June 9, 1999, relating to the 9.50% Series A Cumulative Redeemable Preferred StockForm 10-QAugust 13, 1999
3.5*Articles Supplementary, dated February 10, 2000, relating to the election to be subject to Subtitle 8 of Title 3 of the Maryland General Corporation LawForm 8-KFebruary 10, 2000
3.6*Articles Supplementary, dated February 10, 2000, relating to the Series A Junior Participating Preferred StockForm 8-KFebruary 10, 2000
3.7*Articles Supplementary, dated January 18, 2002, relating to the 9.10% Series B Cumulative Redeemable Preferred StockForm 8-AJanuary 18, 2002
3.8*Articles Supplementary, dated June 22, 2004, relating to the 8.375% Series C Cumulative Redeemable Preferred StockForm 8-AJune 28, 2004
3.9*Articles Supplementary, dated March 25, 2008, relating to the 7.00% Series D Cumulative Convertible Preferred StockForm 8-KMarch 25, 2008
3.10*Articles Supplementary, dated March 12, 2012, relating to the 6.45% Series E Cumulative Redeemable Preferred StockForm 8-KMarch 14, 2012
3.11*Articles Supplementary, dated May 10, 2017, relating to Reclassified Preferred StockForm 8-KMay 12, 2017
3.12*Amended and Restated Bylaws of the Company (Amended July 27, 2018)Form 8-KAugust 2, 2018
4.1*Specimen certificate representing shares of common stockForm 10-QMay 5, 2011
4.2*Indenture, dated as of February 29, 2012, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and the Bank of New York Mellon Trust Company, N.A., as TrusteeForm 8-KFebruary 29, 2012
4.3*Supplemental Indenture No. 4, dated as of July 18, 2014, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and the Bank of New York Mellon Trust Company, N.A., as TrusteeForm 8-KJuly 18, 2014
Exhibit NumberExhibit TitleIncorporated by Reference to:Date Filed
4.4*Form of 4.500% Senior Note due 2029 (included in Exhibit 4.3 above)Form 8-KJuly 18, 2014
4.5*Indenture, dated as of November 17, 2015, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Wilmington Trust, National Association, as TrusteeForm 8-KNovember 17, 2015
4.6*Supplemental Indenture No. 1, dated as of November 17, 2015, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Wilmington Trust, National Association, as TrusteeForm 8-KNovember 17, 2015
4.7*Form of 4.30% Senior Note due 2026 (included in Exhibit 4.6 above)Form 8-KNovember 17, 2015
4.8*Supplemental Indenture No. 2, dated as of June 10, 2016, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Wilmington Trust, National Association, as TrusteeForm 8-KJune 10, 2016
4.9*Form of 3.95% Senior Note due 2027 (included in Exhibit 4.8 above)Form 8-KJune 10, 2016
4.10*Indenture, dated as of March 3, 2017, among the Company, as Issuer Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KMarch 3, 2017
4.11*Supplemental Indenture No. 1, dated as of March 3, 2017, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KMarch 3, 2017
4.12*Form of 3.95% Senior Note due 2028 (included in Exhibit 4.11 above)Form 8-KMarch 3, 2017
4.13*Supplemental Indenture No. 2, dated as of November 20, 2017, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KNovember 20, 2017
4.14*Form of 3.45% Senior Note due 2025 (included in Exhibit 4.13 above)Form 8-KNovember 20, 2017
4.15*Supplemental Indenture No. 3, dated as of June 21, 2018, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KJune 21, 2018
4.16*Supplemental Indenture No. 4, dated as of June 21, 2018, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KJune 21, 2018
4.17*Form of 4.700% Senior Note Due 2030 (included in Exhibit 4.16 above)Form 8-KJune 21, 2018
4.18*Supplemental Indenture No. 5, dated as of March 21, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KMarch 21, 2019
4.19*Form of 3.800% Senior Note Due 2026 (included in Exhibit 4.18 above)Form 8-KMarch 21, 2019
4.20*Supplemental Indenture No. 6, dated as of March 21, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KMarch 21, 2019
4.21*Form of 4.850% Senior Note Due 2049 (included in Exhibit 4.20 above)Form 8-KMarch 21, 2019
4.22*Supplemental Indenture No. 8, dated as of July 15, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KJuly 15, 2019
4.23*Form of 3.375% Senior Note Due 2031 (included in Exhibit 4.22 above)Form 8-KJuly 15, 2019
4.24*Supplemental Indenture No. 9, dated as of July 15, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KJuly 15, 2019
4.25*Supplemental Indenture No. 11 dated as of September 12, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KSeptember 12, 2019
4.26*Form of 4.000% Senior Note Due 2050 (included in Exhibit 4.25 above)Form 8-KJuly 15, 2019
4.27*Supplemental Indenture No. 10, dated as of September 12, 2019, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KSeptember 12, 2019
4.28*Form of 2.750% Senior Note Due 2029 (included in Exhibit 4.27 above)Form 8-KSeptember 12, 2019
Exhibit NumberExhibit TitleIncorporated by Reference to:Date Filed
4.29*Supplemental Indenture No. 12, dated as of March 26, 2020, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Branch Banking and Trust Company, as TrusteeForm 8-KMarch 26, 2020
4.30*Form of 4.900% Senior Note due 2030 (included in Exhibit 4.29 above)Form 8-KMarch 26, 2020
4.31*Supplemental Indenture No. 13, dated August 5, 2020, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Trust Bank, as TrusteeForm 8-KAugust 5, 2020
4.32*Form of 1.875% Senior Notes due 2033 (included in Exhibit 4.31 above)Form 8-KAugust 5, 2020
4.33*Supplemental Indenture No. 14, dated February 18, 2021, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Trust Bank, as TrusteeForm 8-KFebruary 18, 2021
4.34*Form of 2.000 % Senior Notes due 2032 (included in Exhibit 4.33 above)Form 8-KFebruary 18, 2021
4.35*Supplemental Indenture No. 15, dated February 18, 2021, among the Company, as Issuer, Alexandria Real Estate Equities, L.P., as Guarantor, and Trust Bank, as TrusteeForm 8-KFebruary 18, 2021
4.36*Form of 3.000 % Senior Notes due 2051 (included in Exhibit 4.35 above)Form 8-KFebruary 18, 2021
4.37*Description of Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934Form 10-KFebruary 4, 2020
10.1*Credit Agreement, effective as of October 6, 2020, among the Company, as the Borrower, Alexandria Real Estate Equities, L.P., as a Guarantor, Citibank, N.A., as Administrative Agent, and the Other Lenders Party thereto, Citibank, N.A., BofA Securities, Inc., JPMorgan Chase Bank, N.A., Goldman Sachs Bank USA, RBC Capital Markets, Bank of Nova Scotia, Mizuho Bank, Ltd., Sumitomo Mitsui Banking Corporation, and U.S. Bank National Association, as Joint Lead Arrangers, Citibank, N.A., BofA Securities, Inc, JPMorgan Chase Bank, N.A., Goldman Sachs Bank USA, and RBC Capital Markets, as Joint Bookrunners, Bank of America, N.A., JPMorgan Chase Bank, N.A., Goldman Sachs Bank USA, and Royal Bank of Canada, as Co-Syndication Agents, and Bank of Nova Scotia, Mizuho Bank, Ltd., Sumitomo Mitsui Banking Corporation, U.S. Bank National Association, Bank of the West, Barclays Bank PLC, Capital One, N.A., BBVA USA f/k/a Compass Bank, Fifth Third Bank, PNC Bank, National Association, Regions Bank, TD Bank, N.A., and Truist Bank, as Co-Documentation AgentsForm 10-KFebruary 1, 2021
10.2*(1)Amended and Restated 1997 Stock Award and Incentive Plan of the CompanyForm 8-KJune 9, 2020
10.3*(1)Form of Non-Employee Director Stock Option Agreement for use in connection with options issued pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm S-11May 5, 1997
10.4*(1)Form of Incentive Stock Option Agreement for use in connection with options issued pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm S-11May 5, 1997
10.5*(1)Form of Nonqualified Stock Option Agreement for use in connection with options issued pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm S-11May 5, 1997
10.6*(1)Form of Employee Restricted Stock Agreement for use in connection with shares of restricted stock issued to employees pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm 10-KJanuary 30, 2018
10.7*(1)Form of Employee Restricted Stock Agreement (U.S. Affiliate) for use in connection with shares of restricted stock issued to employees pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm 10-KJanuary 30, 2018
10.8*(1)Form of Independent Director Restricted Stock Agreement for use in connection with shares of restricted stock issued to directors pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm 10-KJanuary 30, 2018
10.9*(1)Form of Independent Contractor Restricted Stock Agreement for use in connection with shares of restricted stock issued to independent contractors pursuant to the Amended and Restated 1997 Stock Award and Incentive PlanForm 10-KJanuary 30, 2018
Exhibit NumberExhibit TitleIncorporated by Reference to:Date Filed
10.10*(1)The Company’s 2000 Deferred Compensation Plan, amended and restated effective as of January 1, 2010Form 10-KMarch 1, 2011
10.11*(1)The Company’s 2000 Deferred Compensation Plan for Directors, amended and restated effective as of January 1, 2010Form 10-KMarch 1, 2011
10.12*(1)Amended and Restated Executive Employment Agreement, effective as of January 1, 2015, by and between the Company and Joel S. MarcusForm 8-KApril 7, 2015
10.13*(1)Letter Amendment to Amended and Restated Executive Employment Agreement, dated July 3, 2017, by and between the Company and Joel S. MarcusForm 8-KJuly 3, 2017
10.14*(1)Letter Amendment to Amended and Restated Executive Employment Agreement, entered into on March 20, 2018, by and between the Company and Joel S. MarcusForm 10-QMay 1, 2018
10.15*(1)Letter Amendment to Amended and Restated Executive Employment Agreement, dated January 15, 2019, by and between the Company and Joel S. MarcusForm 8-KJanuary 18, 2019
10.16*(1)Letter Amendment to Amended and Restated Executive Employment Agreement, dated June 8, 2020, by and between the Company and Joel S. MarcusForm 10-QJuly 27, 2020
10.17*(1)Fifth Amended and Restated Executive Employment Agreement between the Company and Stephen A. Richardson, entered into on March 20, 2018 and effective as of April 23, 2018Form 10-QMay 1, 2018
10.18*(1)Third Amended and Restated Executive Employment Agreement between the Company and Peter M. Moglia, entered into on May 22, 2018 and effective as of May 22, 2018Form 10-QJuly 31, 2018
10.19*(1)Fourth Amended and Restated Executive Employment Agreement between the Company and Dean A. Shigenaga, entered into on March 20, 2018 and effective as of April 23, 2018Form 10-QMay 1, 2018
10.20*(1)Executive Employment Agreement between the Company and Daniel J. Ryan, entered into on May 22, 2018 and effective as of May 22, 2018Form 10-QJuly 31, 2018
10.21*(1)Second Amended and Restated Executive Employment Agreement between the Company and John H. Cunningham, entered into on July 5, 2017 and effective as of July 5, 2017Form 10-KFebruary 1, 2021
10.22*(1)Second Amended and Restated Executive Employment Agreement between the Company and Vincent R. Ciruzzi, Jr., entered into on October 1, 2015 and effective as of October 1, 2015Form 10-KFebruary 1, 2021
10.23(1)Executive Employment Agreement between the Company and Hunter Kass, entered into on January 1, 2021 and effective as of January 1, 2021N/AFiled herewith
10.24*(1)Amended and Restated Consulting Agreement, dated as of September 30, 2011, between the Company and James H. RichardsonForm 10-QNovember 9, 2011
10.25(1)Summary of Director Compensation ArrangementsN/AFiled herewith
10.26*(1)Anniversary Bonus Plan of the CompanyForm 8-KJune 17, 2010
10.27*(1)Form of Indemnification Agreement between the Company and each of its directors and officersForm 10-KMarch 1, 2011
14.1The Company’s Business Integrity Policy and Procedures for Reporting Non-Compliance (code of ethics pursuant to Item 406 of Regulation S-K)N/AFiled herewith
21.1List of Subsidiaries of the CompanyN/AFiled herewith
22.1List of Guarantor Subsidiaries of Alexandria Real Estate Equities, Inc.N/AFiled herewith
23.1Consent of Ernst & Young LLPN/AFiled herewith
31.1Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002N/AFiled herewith
31.2Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002N/AFiled herewith
31.3Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002N/AFiled herewith
Exhibit NumberExhibit TitleIncorporated by Reference to:Date Filed
31.4Certification of Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002N/AFiled herewith
32.0Certification of Principal Executive Officers and Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002N/AFiled herewith
101.1The following materials from the Company’s annual report on Form 10-K for the year ended December 31, 2021, formatted in iXBRL (Inline eXtensible Business Reporting Language): (i) Consolidated Balance Sheets as of December 31, 2021 and 2020, (ii) Consolidated Statements of Operations for the years ended December 31, 2021, 2020, and 2019, (iii) Consolidated Statements of Comprehensive Income for the years ended December 31, 2021, 2020, and 2019, (iv) Consolidated Statements of Changes in Stockholders’ Equity and Noncontrolling Interests for the years ended December 31, 2021, 2020, and 2019, (v) Consolidated Statements of Cash Flows for the years ended December 31, 2021, 2020, and 2019, (vi) Notes to Consolidated Financial Statements, and (vii) Schedule III - Consolidated Financial Statement Schedule of Real Estate and Accumulated Depreciation of the Company.N/AFiled herewith
104Cover Page Interactive Data File (embedded within the Inline XBRL document)N/AFiled herewith

(*) Incorporated by reference.

(1) Management contract or compensatory arrangement.

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this annual report on Form 10-K to be signed on its behalf by the undersigned, thereunto duly authorized.

ALEXANDRIA REAL ESTATE EQUITIES, INC.
Dated:January 31, 2022By:/s/ Joel S. Marcus
Joel S. Marcus Executive Chairman (Principal Executive Officer)
/s/ Stephen A. Richardson
Stephen A. Richardson Co-Chief Executive Officer (Principal Executive Officer)
/s/ Peter M. Moglia
Peter M. Moglia Co-Chief Executive Officer and Co-Chief Investment Officer (Principal Executive Officer)

S-1

KNOW ALL THOSE BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Joel S. Marcus, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place, and stead, in any and all capacities, to sign any and all amendments to this annual report on Form 10-K, and to file the same, with exhibits thereto and other documents in connection therewith, if any, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent of their substitute or substitutes may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, this annual report on Form 10-K has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.

SignatureTitleDate
/s/ Joel S. MarcusExecutive Chairman (Principal Executive Officer)January 31, 2022
Joel S. Marcus
/s/ Stephen A. RichardsonCo-Chief Executive Officer (Principal Executive Officer)January 31, 2022
Stephen A. Richardson
/s/ Peter M. MogliaCo-Chief Executive Officer and Co-Chief Investment Officer (Principal Executive Officer)January 31, 2022
Peter M. Moglia
/s/ Dean A. ShigenagaPresident and Chief Financial Officer (Principal Financial Officer)January 31, 2022
Dean A. Shigenaga
/s/ Andres R. GavinetChief Accounting Officer (Principal Accounting Officer)January 31, 2022
Andres R. Gavinet
/s/ Steven R. HashLead DirectorJanuary 31, 2022
Steven R. Hash
/s/ James P. CainDirectorJanuary 31, 2022
James P. Cain
/s/ Maria C. FreireDirectorJanuary 31, 2022
Maria C. Freire
/s/ Jennifer Friel GoldsteinDirectorJanuary 31, 2022
Jennifer Friel Goldstein
/s/ Richard H. KleinDirectorJanuary 31, 2022
Richard H. Klein
/s/ Michael A. WoronoffDirectorJanuary 31, 2022
Michael A. Woronoff

S-2

Report of Independent Registered Public Accounting Firm

To the Stockholders and Board of Directors of Alexandria Real Estate Equities, Inc.

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of Alexandria Real Estate Equities, Inc. (the Company), as of December 31, 2021 and 2020, and the related consolidated statements of operations, comprehensive income, changes in stockholders’ equity and noncontrolling interests and cash flows for each of the three years in the period ended December 31, 2021, and the related notes and financial statement schedule listed in the Index at Item 15 (collectively referred to as the “consolidated financial statements”). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2021 and 2020, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2021, in conformity with U.S. generally accepted accounting principles.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the Company’s internal control over financial reporting as of December 31, 2021, based on criteria established in Internal Control - Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) and our report dated January 31, 2022 expressed an unqualified opinion thereon.

Basis for Opinion

These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial statements based on our audits. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

F-1

Critical Audit Matter

The critical audit matter communicated below is a matter arising from the current period audit of the financial statements that was communicated or required to be communicated to the audit committee and that: (1) relates to accounts or disclosures that are material to the financial statements and (2) involved our especially challenging, subjective, or complex judgments. The communication of the critical audit matter does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing a separate opinion on the critical audit matter or on the accounts or disclosures to which it relates.

Recognition of acquired real estate – Purchase price accounting

Description of the MatterAs more fully disclosed in Notes 2 and 3 to the consolidated financial statements, during 2021, the Company completed the acquisition of 87 properties for a total purchase price of $5.5 billion. The transactions were accounted for as asset acquisitions, and the purchase prices were allocated based on the relative fair values of the assets acquired (including land, buildings and improvements, right-of-use assets, and the intangible value of acquired above-market leases, acquired in-place leases, tenant relationships and other intangible assets) and liabilities assumed (including the intangible value of acquired below-market leases and other intangible liabilities). The fair value of tangible and intangible assets and liabilities is based on available comparable market information, including estimated replacement costs, rental rates, recent market transactions, and estimated cash flow projections that utilize appropriate discount and capitalization rates. Estimates of future cash flows are based on a number of factors, including the historical operating results, known and anticipated trends, and market or economic conditions, that may affect the property. Auditing the Company’s estimate of the fair value of the acquired tangible and intangible assets and liabilities involves significant estimation uncertainty due to the judgment used by management in selecting key assumptions based on recent comparable transactions or market data, which are primarily unobservable inputs, and the sensitivity of the estimates to changes in assumptions. The allocation of purchase price to the components of properties acquired could have an effect on the Company’s net income due to the useful depreciable and amortizable lives applicable to each component and the recognition and classification of the related depreciation or amortization expense in the Company’s consolidated statements of operations.
How we Addressed the Matter in Our AuditOur audit procedures related to the key assumptions utilized in the Company’s purchase price accounting for acquired real estate included the following procedures, among others: We tested the design and operating effectiveness of controls over the Company’s process for determining and reviewing the key inputs and assumptions used in estimating the fair value of acquired assets and liabilities and allocating purchase price to the various components. We evaluated the incorporation of the key assumptions in the purchase price accounting model and recalculated the model’s results. To test the fair values of acquired tangible and intangible assets and liabilities used in the purchase price allocation, we performed procedures to evaluate the valuation methods and significant assumptions used by management. We evaluated the completeness and accuracy of the underlying data supporting the determination of the various inputs. Our internal valuation specialists assisted us in evaluating the methodology used by the Company and considered the consistency of the land and building values, estimated replacement costs, market rental rates, ground lease rates and discount rates with external data sources.

/s/ Ernst & Young LLP

We have served as the Company’s auditor since 1994.

Los Angeles, California

January 31, 2022

F-2

Alexandria Real Estate Equities, Inc. Consolidated Balance Sheets

(In thousands, except share and per share amounts)

December 31,
20212020
Assets
Investments in real estate$24,980,669$18,092,372
Investments in unconsolidated real estate joint ventures38,483332,349
Cash and cash equivalents361,348568,532
Restricted cash53,87929,173
Tenant receivables7,3797,333
Deferred rent839,335722,751
Deferred leasing costs402,898272,673
Investments1,876,5641,611,114
Other assets1,658,8181,191,581
Total assets$30,219,373$22,827,878
Liabilities, Noncontrolling Interests, and Equity
Secured notes payable$205,198$230,925
Unsecured senior notes payable8,316,6787,232,370
Unsecured senior line of credit and commercial paper269,99099,991
Accounts payable, accrued expenses, and other liabilities2,210,4101,669,832
Dividends payable183,847150,982
Total liabilities11,186,1239,384,100
Commitments and contingencies
Redeemable noncontrolling interests9,61211,342
Alexandria Real Estate Equities, Inc.’s stockholders’ equity:
Common stock, $0.01 par value per share, 200,000,000 shares authorized as of December 31, 2021 and 2020; 158,043,880 and 136,690,329 shares issued and outstanding as of December 31, 2021 and 2020, respectively1,5801,367
Additional paid-in capital16,195,25611,730,970
Accumulated other comprehensive loss(7,294)(6,625)
Alexandria Real Estate Equities, Inc.’s stockholders’ equity16,189,54211,725,712
Noncontrolling interests2,834,0961,706,724
Total equity19,023,63813,432,436
Total liabilities, noncontrolling interests, and equity$30,219,373$22,827,878

The accompanying notes are an integral part of these consolidated financial statements.

F-3

Alexandria Real Estate Equities, Inc.

Consolidated Statements of Operations

(In thousands, except per share amounts)

Year Ended December 31,
202120202019
Revenues:
Income from rentals$2,108,249$1,878,208$1,516,864
Other income5,9017,42914,432
Total revenues2,114,1501,885,6371,531,296
Expenses:
Rental operations623,555530,224445,492
General and administrative151,461133,341108,823
Interest142,165171,609173,675
Depreciation and amortization821,061698,104544,612
Impairment of real estate52,67548,07812,334
Loss on early extinguishment of debt67,25360,66847,570
Total expenses1,858,1701,642,0241,332,506
Equity in earnings of unconsolidated real estate joint ventures12,2558,14810,136
Investment income259,477421,321194,647
Gain on sales of real estate126,570154,089474
Net income654,282827,171404,047
Net income attributable to noncontrolling interests(83,035)(56,212)(40,882)
Net income attributable to Alexandria Real Estate Equities, Inc.’s stockholders571,247770,959363,165
Dividends on preferred stock——(3,204)
Preferred stock redemption charge——(2,580)
Net income attributable to unvested restricted stock awards(7,848)(10,168)(6,386)
Net income attributable to Alexandria Real Estate Equities, Inc.’s common stockholders$563,399$760,791$350,995
Net income per share attributable to Alexandria Real Estate Equities, Inc.’s common stockholders:
Basic$3.83$6.03$3.13
Diluted$3.82$6.01$3.12

The accompanying notes are an integral part of these consolidated financial statements.

F-4

Alexandria Real Estate Equities, Inc.

Consolidated Statements of Comprehensive Income

(In thousands)

Year Ended December 31,
202120202019
Net income$654,282$827,171$404,047
Other comprehensive (loss) income
Unrealized losses on interest rate hedge agreements:
Unrealized interest rate hedge losses during the period——(1,763)
Reclassification of amortization to interest expense included in net income——(1,777)
Reclassification of losses related to terminated interest rate hedge instruments to interest expense included in net income——1,702
Unrealized losses on interest rate hedge agreements, net——(1,838)
Unrealized (losses) gains on foreign currency translation:
Unrealized foreign currency translation (losses) gains arising during the period(669)3,1242,524
Unrealized (losses) gains on foreign currency translation, net(669)3,1242,524
Total other comprehensive (loss) income(669)3,124686
Comprehensive income653,613830,295404,733
Less: comprehensive income attributable to noncontrolling interests(83,035)(56,212)(40,882)
Comprehensive income attributable to Alexandria Real Estate Equities, Inc.’s stockholders$570,578$774,083$363,851

The accompanying notes are an integral part of these consolidated financial statements.

F-5

Alexandria Real Estate Equities, Inc.

Consolidated Statements of Changes in Stockholders’ Equity and Noncontrolling Interests

(Dollars in thousands)

Alexandria Real Estate Equities, Inc.’s Stockholders’ Equity
7.00% Series D Cumulative Convertible Preferred StockNumber of Common SharesCommon StockAdditional Paid-In CapitalRetained EarningsAccumulated Other Comprehensive IncomeNoncontrolling InterestsTotal EquityRedeemable Noncontrolling Interests
Balance as of December 31, 2018$64,336111,011,816$1,110$7,286,954$—$(10,435)$541,963$7,883,928$10,786
Net income————363,165—40,007403,172875
Total other comprehensive income—————686—686—
Contributions from and sales of noncontrolling interests———381,162——753,7771,134,9391,469
Distributions to noncontrolling interests——————(47,395)(47,395)(830)
Issuance of common stock—8,723,076871,216,358———1,216,445—
Issuance pursuant to stock plan—666,836767,906———67,913—
Taxes related to net settlement of equity awards—(179,008)(2)(25,475)———(25,477)—
Repurchases of 7.00% Series D preferred stock(6,875)——215(2,580)——(9,240)—
Conversion of 7.00% Series D preferred stock(57,461)577,595657,355———(100)—
Dividends declared on common stock ($4.00 per share)————(463,964)——(463,964)—
Dividends declared on preferred stock ($1.3125 per share)————(3,204)——(3,204)—
Cumulative effect of adjustment upon adoption of lease ASUs on January 1, 2019————(3,525)——(3,525)—
Reclassification of distributions in excess of earnings———(110,108)110,108————
Balance as of December 31, 2019—120,800,3151,2088,874,367—(9,749)1,288,35210,154,17812,300
Net income————770,959—55,309826,268903
Total other comprehensive income—————3,124—3,124—
Contributions from and sales of noncontrolling interests———267,432——449,726717,158281
Distributions to and redemption of noncontrolling interests——————(86,663)(86,663)(2,142)
Issuance of common stock—15,337,9161532,315,709———2,315,862—
Issuance pursuant to stock plan—688,599783,992———83,999—
Taxes related to net settlement of equity awards—(136,501)(1)(21,321)———(21,322)—
Dividends declared on common stock ($4.24 per share)————(557,684)——(557,684)—
Cumulative effect of adjustment upon adoption of credit loss ASU on January 1, 2020————(2,484)——(2,484)—
Reclassification of earnings in excess of distributions———210,791(210,791)————
Balance as of December 31, 2020$—136,690,329$1,367$11,730,970$—$(6,625)$1,706,724$13,432,436$11,342

F-6

Alexandria Real Estate Equities, Inc.

Consolidated Statements of Changes in Stockholders’ Equity and Noncontrolling Interests (continued)

(Dollars in thousands)

Alexandria Real Estate Equities, Inc.’s Stockholders’ Equity
Number of Common SharesCommon StockAdditional Paid-In CapitalRetained EarningsAccumulated Other Comprehensive IncomeNoncontrolling InterestsTotal EquityRedeemable Noncontrolling Interests
Balance as of December 31, 2020136,690,329$1,367$11,730,970$—$(6,625)$1,706,724$13,432,436$11,342
Net income———571,247—82,169653,416866
Total other comprehensive loss————(669)—(669)—
Contributions from and sales of noncontrolling interests——989,393——1,157,6682,147,061282
Distributions to and redemption of noncontrolling interests—————(112,465)(112,465)(2,878)
Issuance of common stock20,827,0522083,528,889———3,529,097—
Issuance pursuant to stock plan709,737797,926———97,933—
Taxes related to net settlement of equity awards(183,238)(2)(34,336)———(34,338)—
Dividends declared on common stock ($4.48 per share)———(688,833)——(688,833)—
Reclassification of distributions in excess of earnings——(117,586)117,586————
Balance as of December 31, 2021158,043,880$1,580$16,195,256$—$(7,294)$2,834,096$19,023,638$9,612

The accompanying notes are an integral part of these consolidated financial statements.

F-7

Alexandria Real Estate Equities, Inc. Consolidated Statements of Cash Flows (In thousands)
Year Ended December 31,
202120202019
Operating Activities
Net income$654,282$827,171$404,047
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization821,061698,104544,612
Impairment of real estate52,67548,07812,334
Gain on sales of real estate(126,570)(154,089)(474)
Loss on early extinguishment of debt67,25360,66847,570
Equity in earnings of unconsolidated real estate joint ventures(12,255)(8,148)(10,136)
Distributions of earnings from unconsolidated real estate joint ventures20,3505,9082,796
Amortization of loan fees11,44110,4949,105
Amortization of debt premiums(2,041)(3,555)(3,777)
Amortization of acquired above- and below-market leases(54,780)(57,244)(29,813)
Deferred rent(115,145)(96,676)(104,235)
Stock compensation expense48,66943,50243,640
Investment income(259,477)(421,321)(194,647)
Changes in operating assets and liabilities:
Tenant receivables(44)2,804(897)
Deferred leasing costs(131,560)(61,067)(54,455)
Other assets(24,591)(10,997)(20,825)
Accounts payable, accrued expenses, and other liabilities60,929(1,122)39,012
Net cash provided by operating activities1,010,197882,510683,857
Investing Activities
Proceeds from sales of real estate190,576747,0206,619
Additions to real estate(2,089,849)(1,445,171)(1,224,541)
Purchases of real estate(5,434,652)(2,570,693)(2,259,778)
Change in escrow deposits(161,696)7,408(18,107)
Sales of interest in unconsolidated real estate joint ventures394,952——
Acquisitions of interest in unconsolidated real estate joint venture(9,048)——
Investments in unconsolidated real estate joint ventures(13,666)(3,444)(102,081)
Return of capital from unconsolidated real estate joint ventures—20,22514
Additions to non-real estate investments(408,564)(174,655)(190,778)
Sales of and distributions from non-real estate investments424,623141,149147,332
Net cash used in investing activities$(7,107,324)$(3,278,161)$(3,641,320)

F-8

Alexandria Real Estate Equities, Inc. Consolidated Statements of Cash Flows (In thousands)
Year Ended December 31,
202120202019
Financing Activities
Borrowings from secured notes payable$10,005$—$—
Repayments of borrowings from secured notes payable(17,979)(84,104)(306,199)
Payment for the defeasance of secured note payable—(32,865)—
Proceeds from issuance of unsecured senior notes payable1,743,7161,697,6512,721,169
Repayments of unsecured senior notes payable(650,000)(500,000)(950,000)
Borrowings from unsecured senior line of credit3,521,0002,700,0005,056,000
Repayments of borrowings from unsecured senior line of credit(3,521,000)(3,084,000)(4,880,000)
Proceeds from issuance under commercial paper program30,951,30023,539,4002,233,000
Repayments of borrowings from commercial paper program(30,781,300)(23,439,400)(2,233,000)
Repayments of borrowings from unsecured senior bank term loan——(350,000)
Premium paid for early extinguishment of debt(66,829)(54,385)(41,351)
Payments of loan fees(18,938)(32,309)(27,182)
Taxes paid related to net settlement of equity awards(34,338)(21,322)(25,477)
Repurchase of 7.00% Series D cumulative convertible preferred stock——(9,240)
Proceeds from issuance of common stock3,529,0972,315,8621,216,445
Dividends on common stock(655,968)(532,980)(447,029)
Dividends on preferred stock——(4,141)
Contributions from and sales of noncontrolling interests2,026,486367,6131,022,712
Distributions to and purchases of noncontrolling interests(118,891)(88,805)(48,225)
Net cash provided by financing activities5,916,3612,750,3562,927,482
Effect of foreign exchange rate changes on cash, cash equivalents, and restricted cash(1,712)311540
Net (decrease) increase in cash, cash equivalents, and restricted cash(182,478)355,016(29,441)
Cash, cash equivalents, and restricted cash as of the beginning of period597,705242,689272,130
Cash, cash equivalents, and restricted cash as of the end of period$415,227$597,705$242,689
Supplemental Disclosure and Non-Cash Investing and Financing Activities:
Cash paid during the period for interest, net of interest capitalized$139,471$161,351$146,165
Accrued construction for current-period additions to real estate$474,751$275,454$220,773
Assumption of secured notes payable in connection with purchase of properties$—$—$(28,200)
Right-of-use asset$103,860$87,554$269,189
Lease liability$(103,860)$(87,554)$(275,175)
Consolidation of real estate assets in connection with our acquisition of partner’s interest in unconsolidated real estate joint venture$19,613$—$—
Assumption of secured note payable in connection with acquisition of partner’s interest in unconsolidated real estate joint venture$(14,558)$—$—
Deferred purchase price in connection with acquisitions of real estate$(81,119)$—$—
Assignment of secured notes payable in connection with sale of real estate$28,200$—$—
Contribution of assets from real estate joint venture partner$118,750$350,000$115,167
Issuance of noncontrolling interest to joint venture partner$(118,750)$(292,930)$—
Issuance of common stock for conversion of 7.00% Series D preferred stock$—$—$57,461

The accompanying notes are an integral part of these consolidated financial statements.

F-9

Alexandria Real Estate Equities, Inc.

Notes to Consolidated Financial Statements

1. ORGANIZATION AND BASIS OF PRESENTATION

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office REIT, is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $44.0 billion as of December 31, 2021, and an asset base in North America of 67.0 million SF. As used in this annual report on Form 10-K, references to the “Company,” “Alexandria,” “ARE,” “we,” “us,” and “our” refer to Alexandria Real Estate Equities, Inc. and its consolidated subsidiaries. The accompanying consolidated financial statements include the accounts of Alexandria Real Estate Equities, Inc. and its consolidated subsidiaries. All significant intercompany balances and transactions have been eliminated.

Any references to our market capitalization, number or quality of buildings or tenants, quality of location, square footage, number of leases, or occupancy percentage, and any amounts derived from these values in these notes to consolidated financial statements are unaudited.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Consolidation

On an ongoing basis, as circumstances indicate the need for reconsideration, we evaluate each legal entity that is not wholly owned by us in accordance with the consolidation guidance. Our evaluation considers all of our variable interests, including equity ownership, as well as fees paid to us for our involvement in the management of each partially owned entity. To fall within the scope of the consolidation guidance, an entity must meet both of the following criteria:

  • The entity has a legal structure that has been established to conduct business activities and to hold assets; such entity can be in the form of a partnership, limited liability company, or corporation, among others; and

  • We have a variable interest in the legal entity – i.e., variable interests that are contractual, such as equity ownership, or other financial interests that change with changes in the fair value of the entity’s net assets.

If an entity does not meet both criteria above, we apply other accounting literature, such as the cost or equity method of accounting. If an entity does meet both criteria above, we evaluate such entity for consolidation under either the variable interest model if the legal entity meets any of the following characteristics to qualify as a VIE, or under the voting model for all other legal entities that are not VIEs.

A legal entity is determined to be a VIE if it has any of the following three characteristics:

  1. The entity does not have sufficient equity to finance its activities without additional subordinated financial support;

  2. The entity is established with non-substantive voting rights (i.e., the entity deprives the majority economic interest holder(s) of voting rights); or

  3. The equity holders, as a group, lack the characteristics of a controlling financial interest. Equity holders meet this criterion if they lack any of the following:

  • The power, through voting rights or similar rights, to direct the activities of the entity that most significantly influence the entity’s economic performance, as evidenced by:

  • Substantive participating rights in day-to-day management of the entity’s activities; or

  • Substantive kick-out rights over the party responsible for significant decisions;

  • The obligation to absorb the entity’s expected losses; or

  • The right to receive the entity’s expected residual returns.

Our real estate joint ventures consist of limited partnerships or limited liability companies. For an entity structured as a limited partnership or a limited liability company, our evaluation of whether the equity holders (equity partners other than the general partner or the managing member of a joint venture) lack the characteristics of a controlling financial interest includes the evaluation of whether the limited partners or non-managing members (the noncontrolling equity holders) lack both substantive participating rights and substantive kick-out rights, defined as follows:

  • Participating rights provide the noncontrolling equity holders the ability to direct significant financial and operating decisions made in the ordinary course of business that most significantly influence the entity’s economic performance.

  • Kick-out rights allow the noncontrolling equity holders to remove the general partner or managing member without cause.

If we conclude that any of the three characteristics of a VIE are met, including that the equity holders lack the characteristics of a controlling financial interest because they lack both substantive participating rights and substantive kick-out rights, we conclude that the entity is a VIE and evaluate it for consolidation under the variable interest model.

F-10

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Variable interest model

If an entity is determined to be a VIE, we evaluate whether we are the primary beneficiary. The primary beneficiary analysis is a qualitative analysis based on power and benefits. We consolidate a VIE if we have both power and benefits — that is, (i) we have the power to direct the activities of a VIE that most significantly influence the VIE’s economic performance (power), and (ii) we have the obligation to absorb losses of or the right to receive benefits from the VIE that could potentially be significant to the VIE (benefits). We consolidate VIEs whenever we determine that we are the primary beneficiary. Refer to Note 4 – “Consolidated and unconsolidated real estate joint ventures” to our consolidated financial statements for information on specific joint ventures that qualify as VIEs. If we have a variable interest in a VIE but are not the primary beneficiary, we account for our investment using the equity method of accounting.

Voting model

If a legal entity fails to meet any of the three characteristics of a VIE (i.e., insufficiency of equity, existence of non-substantive voting rights, or lack of a controlling financial interest), we then evaluate such entity under the voting model. Under the voting model, we consolidate the entity if we determine that we, directly or indirectly, have greater than 50% of the voting shares and that other equity holders do not have substantive participating rights. Refer to Note 4 – “Consolidated and unconsolidated real estate joint ventures” to our consolidated financial statements for further information on our unconsolidated real estate joint ventures that qualify for evaluation under the voting model.

Use of estimates

The preparation of consolidated financial statements in conformity with GAAP requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, and equity; the disclosure of contingent assets and liabilities as of the date of the consolidated financial statements; and the amounts of revenues and expenses during the reporting period. Actual results could materially differ from those estimates.

Reportable segment

We are engaged in the business of providing space for lease to life science, agtech, and technology tenants. Our properties are similar in that they provide space for lease to the aforementioned industries, consist of improvements that are generic and reusable, are primarily located in AAA urban innovation cluster locations, and have similar economic characteristics. Our chief operating decision makers review financial information for our entire consolidated operations when making decisions related to assessing our operating performance, and review financial information for our individual properties when determining how to allocate resources related to capital expenditures. We have aggregated the properties into one reportable segment as the properties share similar long-term economic characteristics and have other similarities, including the fact that they are operated using consistent business strategies, are typically located in major metropolitan areas, and have similar tenant mixes. The financial information disclosed herein represents all of the financial information related to our one reportable segment.

Investments in real estate

Evaluation of business combination or asset acquisition

We evaluate each acquisition of real estate or in-substance real estate (including equity interests in entities that predominantly hold real estate assets) to determine whether the integrated set of assets and activities acquired meets the definition of a business and needs to be accounted for as a business combination. An acquisition of an integrated set of assets and activities that does not meet the definition of a business is accounted for as an asset acquisition. If either of the following criteria is met, the integrated set of assets and activities acquired would not qualify as a business:

  • Substantially all of the fair value of the gross assets acquired is concentrated in either a single identifiable asset or a group of similar identifiable assets; or

  • The integrated set of assets and activities is lacking, at a minimum, an input and a substantive process that together significantly contribute to the ability to create outputs (i.e., revenue generated before and after the transaction).

An acquired process is considered substantive if:

  • The process includes an organized workforce (or includes an acquired contract that provides access to an organized workforce) that is skilled, knowledgeable, and experienced in performing the process;

  • The process cannot be replaced without significant cost, effort, or delay; or

  • The process is considered unique or scarce.

F-11

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Generally, our acquisitions of real estate or in-substance real estate do not meet the definition of a business because substantially all of the fair value is concentrated in a single identifiable asset or group of similar identifiable assets (i.e., land, buildings, and related intangible assets) or because the acquisition does not include a substantive process in the form of an acquired workforce or an acquired contract that cannot be replaced without significant cost, effort, or delay. When evaluating acquired service or management contracts, we consider the nature of the services performed, the terms of the contract relative to similar arm’s-length contracts, and the availability of comparable vendors in evaluating whether the acquired contract constitutes a substantive process.

Recognition of real estate acquired

We evaluate each acquisition of real estate or in-substance real estate (including equity interests in entities that predominantly hold real estate assets) to determine whether the integrated set of assets and activities acquired meets the definition of a business and needs to be accounted for as a business combination. An acquisition of an integrated set of assets and activities that does not meet the definition of a business is accounted for as an asset acquisition.

For acquisitions of real estate or in-substance real estate that are accounted for as business combinations, we allocate the acquisition consideration (excluding acquisition costs) to the assets acquired, liabilities assumed, noncontrolling interests, and previously existing ownership interests at fair value as of the acquisition date. Assets include intangible assets such as tenant relationships, acquired in-place leases, and favorable intangibles associated with in-place leases in which we are the lessor. Liabilities include unfavorable intangibles associated with in-place leases in which we are the lessor. In addition, for acquired in-place finance or operating leases in which we are the lessee, acquisition consideration is allocated to lease liabilities and related right-of-use assets, adjusted to reflect favorable or unfavorable terms of the lease when compared with market terms. Any excess (deficit) of the consideration transferred relative to the fair value of the net assets acquired is accounted for as goodwill (bargain purchase gain). Acquisition costs related to business combinations are expensed as incurred.

Generally, we expect that acquisitions of real estate or in-substance real estate will not meet the definition of a business because substantially all of the fair value is concentrated in a single identifiable asset or group of similar identifiable assets (i.e., land, buildings, and related intangible assets). The accounting model for asset acquisitions is similar to the accounting model for business combinations, except that the acquisition consideration (including acquisition costs) is allocated to the individual assets acquired and liabilities assumed on a relative fair value basis. Any excess (deficit) of the consideration transferred relative to the sum of the fair value of the assets acquired and liabilities assumed is allocated to the individual assets and liabilities based on their relative fair values. As a result, asset acquisitions do not result in the recognition of goodwill or a bargain purchase gain. Incremental and external direct acquisition costs (such as legal and other third-party services) are capitalized.

We exercise judgment to determine the key assumptions used to allocate the purchase price of real estate acquired among its components. The allocation of the consideration to the various components of properties acquired during the year can have an effect on our net income due to the useful depreciable and amortizable lives applicable to each component and the recognition of the related depreciation and amortization expense in our consolidated statements of operations. We apply judgment in utilizing available comparable market information to assess relative fair value. We assess the relative fair values of tangible and intangible assets and liabilities based on available comparable market information, including estimated replacement costs, rental rates, and recent market transactions. In addition, we may use estimated cash flow projections that utilize appropriate discount and capitalization rates. Estimates of future cash flows are based on a number of factors, including the historical operating results, known and anticipated trends, and market/economic conditions that may affect the property.

The value of tangible assets acquired is based upon our estimation of fair value on an “as if vacant” basis. The value of acquired in-place leases includes the estimated costs during the hypothetical lease-up period and other costs that would have been incurred in the execution of similar leases under the market conditions at the acquisition date of the acquired in-place lease. If there is a bargain fixed-rate renewal option for the period beyond the noncancelable lease term of an in-place lease, we evaluate intangible factors such as the business conditions in the industry in which the lessee operates, the economic conditions in the area in which the property is located, and the ability of the lessee to sublease the property during the renewal term, in order to determine the likelihood that the lessee will renew. When we determine there is reasonable assurance that such bargain purchase option will be exercised, we consider the option in determining the intangible value of such lease and its related amortization period. We also recognize the relative fair values of assets acquired, the liabilities assumed, and any noncontrolling interest in acquisitions of less than a 100% interest when the acquisition constitutes a change in control of the acquired entity.

F-12

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

The values allocated to buildings and building improvements, land improvements, tenant improvements, and equipment are depreciated on a straight-line basis using the shorter of the respective ground lease term, estimated useful life, or up to 40 years, for buildings and building improvements; estimated life, or up to 20 years, for land improvements; the respective lease term or estimated useful life for tenant improvements; and the shorter of the lease term or estimated useful life for equipment. The values of the right-of-use assets are amortized on a straight-line basis over the remaining lease term. The values of acquired in-place leases and associated favorable intangibles (i.e., acquired above-market leases) are classified in other assets in our consolidated balance sheets and are amortized over the remaining terms of the related leases as a reduction of income from rentals in our consolidated statements of operations. The values of unfavorable intangibles (i.e., acquired below-market leases) associated with acquired in-place leases are classified in accounts payable, accrued expenses, and other liabilities in our consolidated balance sheets and are amortized over the remaining terms of the related leases as an increase in income from rentals in our statements of operations.

Capitalized project costs

We capitalize project costs, including pre-construction costs, interest, property taxes, insurance, and other costs directly related and essential to the development, redevelopment, pre-construction, or construction of a project. Capitalization of development, redevelopment, pre-construction, and construction costs is required while activities are ongoing to prepare an asset for its intended use. Fluctuations in our development, redevelopment, pre-construction, and construction activities could result in significant changes to total expenses and net income. Costs incurred after a project is substantially complete and ready for its intended use are expensed as incurred. Should development, redevelopment, pre-construction, or construction activity cease, interest, property taxes, insurance, and certain other costs would no longer be eligible for capitalization and would be expensed as incurred. Expenditures for repairs and maintenance are expensed as incurred.

Real estate sales

A property is classified as held for sale when all of the following criteria for a plan of sale have been met: (i) management, having the authority to approve the action, commits to a plan to sell the property; (ii) the property is available for immediate sale in its present condition, subject only to terms that are usual and customary; (iii) an active program to locate a buyer and other actions required to complete the plan to sell have been initiated; (iv) the sale of the property is probable and is expected to be completed within one year; (v) the property is being actively marketed for sale at a price that is reasonable in relation to its current fair value; and (vi) actions necessary to complete the plan of sale indicate that it is unlikely that significant changes to the plan will be made or that the plan will be withdrawn. Depreciation of assets ceases upon designation of a property as held for sale.

If the disposal of a property represents a strategic shift that has (or will have) a major effect on our operations or financial results, such as (i) a major line of business, (ii) a major geographic area, (iii) a major equity method investment, or (iv) other major parts of an entity, then the operations of the property, including any interest expense directly attributable to it, are classified as discontinued operations in our consolidated statements of operations, and amounts for all prior periods presented are reclassified from continuing operations to discontinued operations. The disposal of an individual property generally will not represent a strategic shift and therefore will typically not meet the criteria for classification as a discontinued operation.

We recognize gains or losses on real estate sales in accordance with the accounting standard on the derecognition of nonfinancial assets arising from contracts with noncustomers. Our ordinary output activities consist of the leasing of space to our tenants in our operating properties, not the sales of real estate. Therefore, sales of real estate (in which we are the seller) qualify as contracts with noncustomers. In our transactions with noncustomers, we apply certain recognition and measurement principles consistent with our method of recognizing revenue arising from contracts with customers. Derecognition of the asset is based on the transfer of control. If a real estate sales contract includes our ongoing involvement with the property, then we evaluate each promised good or service under the contract to determine whether it represents a separate performance obligation, constitutes a guarantee, or prevents the transfer of control. If a good or service is considered a separate performance obligation, an allocated portion of the transaction price is recognized as revenue as we transfer the related good or service to the buyer.

The recognition of gain or loss on the sale of a partial interest also depends on whether we retain a controlling or noncontrolling interest in the property. If we retain a controlling interest in the property upon completion of the sale, we continue to reflect the asset at its book value, record a noncontrolling interest for the book value of the partial interest sold, and recognize additional paid-in capital for the difference between the consideration received and the partial interest at book value. Conversely, if we retain a noncontrolling interest upon completion of the sale of a partial interest of real estate, we would recognize a gain or loss as if 100% of the real estate were sold.

Impairment of long-lived assets

Prior to and subsequent to the end of each quarter, we review current activities and changes in the business conditions of all of our long-lived assets to determine the existence of any triggering events or impairment indicators requiring an impairment analysis. If triggering events or impairment indicators are identified, we review an estimate of the future undiscounted cash flows, including, if necessary, a probability-weighted approach if multiple outcomes are under consideration.

F-13

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Long-lived assets to be held and used, including our rental properties, CIP, land held for development, right-of-use assets related to operating leases in which we are the lessee, and intangibles, are individually evaluated for impairment when conditions exist that may indicate that the carrying amount of a long-lived asset may not be recoverable. The carrying amount of a long-lived asset to be held and used is not recoverable if it exceeds the sum of the undiscounted cash flows expected to result from the use and eventual disposition of the asset. Triggering events or impairment indicators for long-lived assets to be held and used are assessed by project and include significant fluctuations in estimated net operating income, occupancy changes, significant near-term lease expirations, current and historical operating and/or cash flow losses, construction costs, estimated completion dates, rental rates, and other market factors. We assess the expected undiscounted cash flows based upon numerous factors, including, but not limited to, construction costs, available market information, current and historical operating results, known trends, current market/economic conditions that may affect the asset, and our assumptions about the use of the asset, including, if necessary, a probability-weighted approach if multiple outcomes are under consideration.

Upon determination that an impairment has occurred, a write-down is recognized to reduce the carrying amount of the asset to its estimated fair value. If an impairment charge is not required to be recognized, the recognition of depreciation or amortization is adjusted prospectively, as necessary, to reduce the carrying amount of the asset to its estimated disposition value over the remaining period that the asset is expected to be held and used. We may adjust depreciation of properties that are expected to be disposed of or redeveloped prior to the end of their useful lives.

We use the held for sale impairment model for our properties classified as held for sale, which is different from the held and used impairment model. Under the held for sale impairment model, an impairment charge is recognized if the carrying amount of the long-lived asset classified as held for sale exceeds its fair value less cost to sell. Because of these two different models, it is possible for a long-lived asset previously classified as held and used to require the recognition of an impairment charge upon classification as held for sale.

International operations

In addition to operating properties in the U.S., we have six operating properties in Canada and one operating property in China. The functional currency for our subsidiaries operating in the U.S. is the U.S. dollar. The functional currencies for our foreign subsidiaries are the local currencies in each respective country. The assets and liabilities of our foreign subsidiaries are translated into U.S. dollars at the exchange rate in effect as of the financial statement date. Revenue and expense accounts of our foreign subsidiaries are translated using the weighted-average exchange rate for the periods presented. Gains or losses resulting from the translation are classified in accumulated other comprehensive income (loss) as a separate component of total equity and are excluded from net income.

Whenever a foreign investment meets the criteria for classification as held for sale, we evaluate the recoverability of the investment under the held for sale impairment model. We may recognize an impairment charge if the carrying amount of the investment exceeds its fair value less cost to sell. In determining an investment’s carrying amount, we consider its net book value and any cumulative unrealized foreign currency translation adjustment related to the investment.

The appropriate amounts of foreign exchange rate gains or losses classified in accumulated other comprehensive income (loss) are reclassified to net income when realized upon the sale of our investment or upon the complete or substantially complete liquidation of our investment.

F-14

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Investments

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. As a REIT, we generally limit our ownership of each individual entity’s voting stock to less than 10%. We account for our investments as follows:

Investments in publicly traded companies

Our investments in publicly traded companies are classified as investments with readily determinable fair values and are presented at fair value in our consolidated balance sheets, with changes in fair value recognized in net income. The fair values for our investments in publicly traded companies are determined based on sales prices or quotes available on securities exchanges.

Investments in privately held companies

Our investments in privately held entities without readily determinable fair values consist of (i) investments in privately held entities that report NAV per share, and (ii) investments in privately held entities that do not report NAV per share. These investments are accounted for as follows:

Investments in privately held entities that report NAV per share

Investments in privately held entities that report NAV per share, such as our privately held investments in limited partnerships, are presented at fair value using NAV as a practical expedient, with changes in fair value recognized in net income. We use NAV per share reported by limited partnerships generally without adjustment, unless we are aware of information indicating that the NAV reported by a limited partnership does not accurately reflect the fair value of the investment at our reporting date. We disclose the timing of liquidation of an investee’s assets and the date when redemption restrictions will lapse (or indicate if this timing is unknown) if the investee has communicated this information to us or has announced it publicly.

Investments in privately held entities that do not report NAV per share

Investments in privately held entities that do not report NAV per share are accounted for using a measurement alternative, under which these investments are measured at cost, adjusted for observable price changes and impairments, with changes recognized in net income.

An observable price arises from an orderly transaction for an identical or similar investment of the same issuer, which is observed by an investor without expending undue cost and effort. Observable price changes result from, among other things, equity transactions of the same issuer executed during the reporting period, including subsequent equity offerings or other reported equity transactions related to the same issuer. To determine whether these transactions are indicative of an observable price change, we evaluate, among other factors, whether these transactions have similar rights and obligations, including voting rights, distribution preferences, and conversion rights to the investments we hold.

Investments accounted for under the equity method

We account for investments under the equity method whenever we are deemed to have significant influence over the investee’s operating and financial policies. To evaluate whether we exert significant influence over an entity, we consider the following criteria, among others: the extent of our ownership and voting rights, whether we have a board seat, and whether we participate in the policy-making process. Under the equity method of accounting, we initially recognize our investment at cost and subsequently adjust the carrying amount of the investment for our share of earnings or losses reported by the investee, distributions received, and other-than-temporary impairments. For more information about our investments accounted for under the equity method, refer to Note 7 – “Investments” to our consolidated financial statements.

Investments in privately held entities that do not report NAV per share and equity method investments

We monitor investments in privately held entities that do not report NAV per share and equity method investments throughout the year for new developments, including operating results, prospects and results of clinical trials, new product initiatives, new collaborative agreements, capital-raising events, and merger and acquisition activities. These investments are evaluated on the basis of a qualitative assessment for indicators of impairment by monitoring the presence of the following triggering events or impairment indicators: (i) a significant deterioration in the earnings performance, asset quality, or business prospects of the investee; (ii) a significant adverse change in the regulatory, economic, or technological environment of the investee, (iii) a significant adverse change in the general market condition, including the research and development of technology and products that the investee is bringing or attempting to bring to the market, (iv) significant concerns about the investee’s ability to continue as a going concern, or (v) a decision by investors to cease providing support or reduce their financial commitment to the investee. If such indicators are present, we estimate the investment’s fair value and recognize an impairment charge in an amount equal to the investment’s carrying value in excess of its estimated fair value.

F-15

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Investment income/loss recognition and classification

We recognize both realized and unrealized gains and losses in our consolidated statements of operations, classified within investment income. Unrealized gains and losses represent:

(1)changes in fair value for investments in publicly traded companies;

(2)changes in NAV as a practical expedient to estimate fair value for investments in privately held entities that report NAV per share;

(3)observable price changes for investments in privately held entities that do not report NAV per share; and

(4)our share of unrealized gains or losses reported by our equity method investees.

Realized gains and losses on our investments represent the difference between proceeds received upon disposition of investments and their historical or adjusted cost. For our equity method investments, realized gains and losses represent our share of realized gains or losses reported by the investee. Impairments are realized losses, which result in an adjusted cost, and represent charges to reduce the carrying values of investments in privately held entities that do not report NAV per share and equity method investments, if impairments are deemed other than temporary, to their estimated fair value.

Revenues

The table below provides details of our consolidated total revenues for the years ended December 31, 2021 and 2020 (in thousands):

Year Ended December 31,
202120202019
Income from rentals:
Revenues subject to the lease accounting standard:
Operating leases$2,081,362$1,854,427$1,465,692
Direct financing and sales-type leases3,4892,4692,421
Revenues subject to the lease accounting standard2,084,8511,856,8961,468,113
Revenues subject to the revenue recognition accounting standard23,39821,31248,751
Income from rentals2,108,2491,878,2081,516,864
Other income5,9017,42914,432
Total revenues$2,114,150$1,885,637$1,531,296

During the year ended December 31, 2021, revenues that were subject to the lease accounting standard aggregated $2.1 billion and represented 98.6% of our total revenues. During the year ended December 31, 2021, our total revenues also included $29.3 million, or 1.4%, subject to other accounting guidance. Our other income consisted primarily of construction management fees and interest income earned during the year ended December 31, 2021. For a detailed discussion related to our revenue streams, refer to the “Lease accounting” and “Recognition of revenue arising from contracts with customers” sections within this Note 2 to our consolidated financial statements.

Lease accounting

Definition and classification of a lease

When we enter into a contract or amend an existing contract, we evaluate whether the contract meets the definition of a lease. To meet the definition of a lease, the contract must meet all three criteria:

(i)One party (lessor) must hold an identified asset;

(ii)The counterparty (lessee) must have the right to obtain substantially all of the economic benefits from the use of the asset throughout the period of the contract; and

(iii)The counterparty (lessee) must have the right to direct the use of the identified asset throughout the period of the contract.

F-16

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

We classify our leases as either finance leases or operating leases if we are the lessee, or sales-type, direct financing, or operating leases if we are the lessor. We use the following criteria to determine if a lease is a finance lease (as a lessee) or sales-type or direct financing lease (as a lessor):

(i)Ownership is transferred from lessor to lessee by the end of the lease term;

(ii)An option to purchase is reasonably certain to be exercised;

(iii)The lease term is for the major part of the underlying asset’s remaining economic life;

(iv)The present value of lease payments equals or exceeds substantially all of the fair value of the underlying asset; or

(v)The underlying asset is specialized and is expected to have no alternative use at the end of the lease term.

If we meet any of the above criteria, we account for the lease as a finance, a sales-type, or a direct financing lease. If we do not meet any of the criteria, we account for the lease as an operating lease.

A lease is accounted for as a sales-type lease if it is considered to transfer control of the underlying asset to the lessee. A lease is accounted for as a direct financing lease if risks and rewards are conveyed without the transfer of control, which is normally indicated by the existence of a residual value guarantee from an unrelated third party other than the lessee.

This classification will determine the method of recognition of the lease:

  • For an operating lease, we recognize income from rentals if we are the lessor, or rental operations expense if we are the lessee, over the term of the lease on a straight-line basis.

  • For a sales-type or direct financing lease, we recognize the income from rentals, or for a finance lease, we recognize rental operations expense, over the term of the lease using the effective interest method.

  • For a sales-type lease, if we determine the fair value of the leased property differs from its carrying amount, a gain or loss may be recognized at inception of the lease.

Lessor accounting

Costs to execute leases

We capitalize initial direct costs, which represent only incremental costs of a lease that would not have been incurred if the lease had not been obtained. Costs that we incur to negotiate or arrange a lease, regardless of its outcome, such as for fixed employee compensation, tax, or legal advice to negotiate lease terms, and other costs, are expensed as incurred.

Operating leases

We account for the revenue from our lease contracts by utilizing the single component accounting policy. This policy requires us to account for, by class of underlying asset, the lease component and nonlease component(s) associated with each lease as a single component if two criteria are met:

(i)The timing and pattern of transfer of the lease component and the nonlease component(s) are the same; and

(ii)The lease component would be classified as an operating lease if it were accounted for separately.

Lease components consist primarily of fixed rental payments, which represent scheduled rental amounts due under our leases, and contingent rental payments. Nonlease components consist primarily of tenant recoveries representing reimbursements of rental operating expenses under our triple net lease structure, including recoveries for utilities, repairs and maintenance, and common area expenses.

If the lease component is the predominant component, we account for all revenues under such lease as a single component in accordance with the lease accounting standard. Conversely, if the nonlease component is the predominant component, all revenues under such lease are accounted for in accordance with the revenue recognition accounting standard. Our operating leases qualify for the single component accounting, and the lease component in each of our leases is predominant. Therefore, we account for all revenues from our operating leases under the lease accounting standard and classify these revenues as income from rentals in our consolidated statements of operations.

We commence recognition of income from rentals related to the operating leases at the date the property is ready for its intended use by the tenant and the tenant takes possession or controls the physical use of the leased asset. Income from rentals related to fixed rental payments under operating leases is recognized on a straight-line basis over the respective operating lease terms. We classify amounts expected to be received in later periods as deferred rent in our consolidated balance sheets. Amounts received currently but recognized as revenue in future periods are classified in accounts payable, accrued expenses, and other liabilities in our consolidated balance sheets.

F-17

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Income from rentals related to variable payments includes tenant recoveries and contingent rental payments. Tenant recoveries, including reimbursements of utilities, repairs and maintenance, common area expenses, real estate taxes and insurance, and other operating expenses, are recognized as revenue in the period during which the applicable expenses are incurred and the tenant’s obligation to reimburse us arises. Income from rentals related to other variable payments is recognized when associated contingencies are removed.

We assess collectibility from our tenants of future lease payments for each of our operating leases. If we determine that collectibility is probable, we recognize income from rentals based on the methodology described above. If we determine that collectibility is not probable, we recognize an adjustment to lower our income from rentals. Furthermore, we may recognize a general allowance at a portfolio level (not the individual level) if we do not expect to collect future lease payments in full.

During the year ended December 31, 2021, we recognized an adjustment aggregating $4.9 million to lower our income from rentals related to certain leases where we determined that the collection of future lease payments was not probable. For these leases, we ceased the recognition of income from rentals on a straight-line basis and began the recognition of income from rentals on a cash basis as lease payments are collected. We will not resume straight-line recognition of income from rentals for these leases until we determine that collectibility of future payments related to these leases is probable.

During the year ended December 31, 2021, we also recorded a general allowance of $3.0 million associated with the increase in our annual rental revenue during 2021 as a result of the continued growth of our operations in multiple markets. This general allowance relates to the deferred rent balances that at the portfolio level (not the individual level) are not expected to be collected in full through the lease term. As of December 31, 2021, our general allowance balance aggregated $6.8 million.

Direct financing and sales-type leases

Income from rentals related to our direct financing and sales-type leases is recognized over the lease term using the effective interest rate method. At lease commencement, we record an asset within other assets in our consolidated balance sheets, which represents our net investment in the lease. This initial net investment is determined by aggregating the present values of the total future lease payments attributable to the lease and the estimated residual value of the property, less any unearned income related to our direct financing lease. Over the lease term, the investment in the lease accretes in value, producing a constant periodic rate of return on the net investment in the lease. Income from these leases is classified in income from rentals in our consolidated statements of operations. Our net investment is reduced over time as lease payments are received.

We evaluate our net investment in the direct financing and sales-type leases for impairment under the current expected credit loss standard that we adopted on January 1, 2020. For more information, refer to the “Allowance for credit losses” section within this Note 2 to our consolidated financial statements.

In July 2021, the FASB issued an ASU that will require a lessor to classify a lease with variable lease payments that do not depend on an index or a rate as an operating lease on the commencement date of the lease if both of the following criteria are met:

(i)The lease would have been classified as a sales-type lease or direct financing lease under the current lease standard; and

(ii)The sales-type lease or direct financing lease classification would have resulted in a selling loss at lease commencement.

Under the new lease ASU, the lessor will not derecognize the underlying asset and will not recognize a loss upon lease commencement but will continue to depreciate the underlying asset over its useful life. Upon adoption of this ASU, lessors are expected to classify more of their leases as operating leases as opposed to sales-type leases or direct financing leases.

The ASU is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2021, with early adoption permitted. The ASU can be applied either (i) retrospectively to leases that commenced or were modified on or after the adoption of the lease accounting standard on January 1, 2019 or (ii) prospectively to leases that commence or are modified on or after the date this ASU is adopted. We adopted this ASU prospectively on January 1, 2022. Historically, substantially all our leases in which we are the lessor have been operating leases; therefore, the adoption of this ASU is not expected to have a material effect on our consolidated financial statements.

Lessee accounting

We have operating lease agreements in which we are the lessee consisting of ground and office leases. At the lease commencement date (or at the acquisition date if the lease is acquired as part of a real estate acquisition), we are required to recognize a liability to account for our future obligations under these operating leases, and a corresponding right-of-use asset.

F-18

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

The lease liability is measured based on the present value of the future lease payments, including payments during the term under our extension options that we are reasonably certain to exercise. The present value of the future lease payments is calculated for each operating lease using each respective remaining lease term and a corresponding estimated incremental borrowing rate, which is the interest rate that we estimate we would have to pay to borrow on a collateralized basis over a similar term for an amount equal to the lease payments. Subsequently, the lease liability is accreted by applying a discount rate established at the lease commencement date to the lease liability balance as of the beginning of the period and is reduced by the payments made during the period. We classify the operating lease liability in accounts payable, accrued expenses, and other liabilities in our consolidated balance sheets.

The right-of-use asset is measured based on the corresponding lease liability, adjusted for initial direct leasing costs and any other consideration exchanged with the landlord prior to the commencement of the lease, as well as adjustments to reflect favorable or unfavorable terms of an acquired lease when compared with market terms at the time of acquisition. Subsequently, the right-of-use asset is amortized on a straight-line basis over the lease term. We classify the right-of-use asset in other assets in our consolidated balance sheets.

Recognition of revenue arising from contracts with customers

We recognize revenues associated with transactions arising from contracts with customers, excluding revenues subject to the lease accounting standard discussed in the “Lease accounting” section above, in accordance with the revenue recognition accounting standard. A customer is distinguished from a noncustomer by the nature of the goods or services that are transferred. Customers are provided with goods or services that are generated by a company’s ordinary output activities, whereas noncustomers are provided with nonfinancial assets that are outside of a company’s ordinary output activities.

We generally recognize revenue representing the transfer of goods and services to customers in an amount that reflects the consideration to which we expect to be entitled in the exchange. In order to determine the recognition of revenue from customer contracts, we use a five-step model to (i) identify the contract with the customer, (ii) identify the performance obligations in the contract, (iii) determine the transaction price, including variable consideration to the extent that it is probable that a significant future reversal will not occur, (iv) allocate the transaction price to the performance obligations in the contract, and (v) recognize revenue when (or as) we satisfy the performance obligation.

We identify contractual performance obligations and determine whether revenue should be recognized at a point in time or over time, based on when control of goods and services transfers to a customer. We consider whether we control the goods or services prior to the transfer to the customer in order to determine whether we should account for the arrangement as a principal or agent. If we determine that we control the goods or services provided to the customer, then we are the principal to the transaction, and we recognize the gross amount of consideration expected in the exchange. If we simply arrange but do not control the goods or services being transferred to the customer, then we are considered to be an agent to the transaction, and we recognize the net amount of consideration we are entitled to retain in the exchange.

Total revenues subject to the revenue recognition accounting standard and classified within income from rentals in our consolidated statements of operations for the year ended December 31, 2021 and 2020, included $23.4 million and $21.3 million, respectively, primarily related to short-term parking revenues associated with long-term lease agreements. Short-term parking revenues do not qualify for the single component accounting policy, discussed in the “Lessor accounting” subsection of the “Lease accounting” section within this Note 2, due to the difference in the timing and pattern of transfer of our parking service obligations and associated lease components within the same lease agreement. We recognize short-term parking revenues in accordance with the revenue recognition accounting standard when the service is provided and the performance obligation is satisfied, which normally occurs at a point in time.

Monitoring of tenant credit quality

During the term of each lease, we monitor the credit quality and any related material changes of our tenants by (i) monitoring the credit rating of tenants that are rated by a nationally recognized credit rating agency, (ii) reviewing financial statements of the tenants that are publicly available or that are required to be delivered to us pursuant to the applicable lease, (iii) monitoring news reports regarding our tenants and their respective businesses, and (iv) monitoring the timeliness of lease payments.

Allowance for credit losses

On January 1, 2020, we adopted an accounting standard (further clarified in subsequently issued updates) that requires companies to estimate and recognize lifetime expected losses, rather than incurred losses, which results in the earlier recognition of credit losses even if the expected risk of credit loss is remote. The accounting standard applies to most financial assets measured at amortized cost and certain other instruments, including trade and other receivables, loans, held-to-maturity debt securities, net investments in leases arising from sales-type and direct financing leases, and off-balance-sheet credit exposures (e.g., loan commitments). The standard does not apply to the receivables arising from operating leases. An assessment of the collectibility of operating lease payments and the recognition of an adjustment to lease income based on this assessment is governed by the lease accounting standard discussed in the “Lease accounting” section earlier within this Note 2 to our consolidated financial statements.

F-19

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

At each reporting date, we reassess our credit loss allowances on the aggregate net investment of our direct financing and sales-type leases and recognize a credit loss adjustment, if necessary, for our current estimate of expected credit losses, which is classified within rental operations in our consolidated statements of operations. For further details, refer to Note 5 – “Leases” to our consolidated financial statements.

Upon adoption of the accounting standard, we had one lease subject to this standard classified as a direct financing lease. In this direct financing lease, the payment obligation of the lessee is collateralized by real estate property. Historically, we have had no collection issues related to this direct financing lease; therefore, we assessed the probability of default on this lease based on the lessee’s financial condition, credit rating, business prospects, remaining lease term, and, in case of the direct financing lease, the expected value of the underlying collateral upon its repossession, and, if necessary, we recognize a credit loss adjustment. Based on the aforementioned considerations, we estimated a credit loss adjustment related to this direct financing lease aggregating $2.2 million, which was recognized as a cumulative adjustment to retained earnings and as a reduction of the investment in the direct financing lease balance in our consolidated balance sheets on January 1, 2020.

In addition to our direct financing and sales-type leases, the accounting standard on credit losses applies to our receivables that result from revenue transactions within the scope of the revenue recognition accounting standard discussed in the “Recognition of revenue arising from contracts with customers” section earlier within this Note 2. Upon adoption of the standard on January 1, 2020, our receivables resulting from revenue transactions within the scope of revenue recognition accounting standard aggregated $16.1 million. Among other factors, we considered the short-term nature of these receivables, our positive assessment of the financial condition and business prospects of the payors, and minimal historical collectibility issues. Based on the aforementioned considerations, we estimated the credit loss related to our trade receivables to approximate $259 thousand, which was recognized as a cumulative adjustment to retained earnings and as a reduction of the trade receivables balance in our consolidated balance sheets on January 1, 2020.

Income taxes

We are organized and operate as a REIT pursuant to the Internal Revenue Code of 1986, as amended (the “Code”). We believe we have qualified and continue to qualify as a REIT. Qualification as a REIT involves the application of highly technical and complex provisions of the Code to our operations and financial results, and the determination of various factual matters and circumstances not entirely within our control. We believe that our current organization and method of operation comply with the rules and regulations promulgated under the Code to enable us to qualify, and continue to qualify, as a REIT. However, it is possible that we have been organized or have operated in a manner that would not allow us to qualify as a REIT, or that our future operations could cause us to fail to qualify.

If we fail to qualify as a REIT in any taxable year, then we will be required to pay federal and state income taxes on our taxable income at regular corporate rates. If we lose our REIT status, then our net earnings available for investment or distribution to our stockholders will be significantly reduced for each of the years involved and we will no longer be required to make distributions to our stockholders.

Under the Code, a REIT that distributes at least 90% of its REIT taxable income to its stockholders annually (excluding net capital gains) and meets certain other conditions is not subject to federal income tax on its distributed taxable income, but could be subject to certain federal, foreign, state, and local taxes. We distribute 100% of our taxable income annually; therefore, a provision for federal income taxes is not required. In addition to our REIT returns, we file federal, foreign, state, and local tax returns for our subsidiaries. We file with jurisdictions located in the U.S., Canada, China, and other international locations. Our tax returns are subject to routine examination in various jurisdictions for the 2015 through 2020 calendar years.

Employee and non-employee share-based payments

We have implemented an entity-wide accounting policy to account for forfeitures of share-based awards granted to employees and non-employees when they occur. As a result of this policy, we recognize expense on share-based awards with time-based vesting conditions without reductions for an estimate of forfeitures. This accounting policy only applies to service condition awards. For performance condition awards, we continue to assess the probability that such conditions will be achieved. Expenses related to forfeited awards are reversed as forfeitures occur. In addition, all nonforfeitable dividends paid on share-based payment awards are initially classified in retained earnings and reclassified to compensation cost only if forfeitures of the underlying awards occur. Our employee and non-employee share-based awards are measured at their fair value on the grant date and recognized over the recipient’s required service period.

F-20

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (continued)

Forward equity sales agreements

We account for our forward equity sales agreements in accordance with the accounting guidance governing financial instruments and derivatives. None of our forward equity sales agreements were deemed to be liabilities as they did not embody obligations to repurchase our shares, nor did they embody obligations to issue a variable number of shares for which the monetary value was predominantly fixed, varied with something other than the fair value of our shares, or varied inversely in relation to our shares. We also evaluated if the agreements met the derivatives and hedging guidance scope exception to be accounted for as equity instruments and concluded that the agreements can be classified as equity contracts based on the following assessment: (i) none of the agreements’ exercise contingencies were based on observable markets or indices besides those related to the market for our own stock price and operations; and (ii) none of the settlement provisions precluded the agreements from being indexed to our own stock.

Issuer and guarantor subsidiaries of guaranteed securities

In March 2020, the SEC issued an amendment to existing guidance to reduce and simplify financial disclosure requirements for issuers and guarantors of registered debt offerings. The guidance became effective for filings on or after January 4, 2021, with early adoption permitted. Upon evaluation of the guidance, we elected to early adopt the amendment during the three months ended March 31, 2020.

Generally, a parent entity must provide separate subsidiary issuer or guarantor financial statements, unless it qualifies for disclosure exceptions provided in the amendment. Under the previous guidance, a parent entity was required to fully own the subsidiary issuer or guarantor and guarantee its registered security fully and unconditionally to qualify for disclosure exceptions. Pursuant to the amendment, a parent entity may be eligible for disclosure exceptions if it meets the following criteria:

  • The subsidiary issuer or guarantor is a consolidated subsidiary of the parent company, and

  • The subsidiary issues a registered security that is:

  • Issued jointly and severally with the parent company, or

  • Fully and unconditionally guaranteed by the parent company.

A parent entity that meets the above criteria may instead present summarized financial information (“alternative disclosures”). We evaluated the criteria and determined that we are eligible for the disclosure exceptions, which allow us to provide alternative disclosures.

The amendment also allows for further simplification of disclosure requirements for entities that qualify for the alternative disclosures. A parent entity was previously required to provide disclosures within the footnotes to the consolidated financial statements. However, the amendment allows for such disclosures to be provided outside of the consolidated financial statements, including within the “Management’s discussion and analysis of financial condition and results of operations” section under Item 7 in this annual report on Form 10-K. As such, since our adoption of the amendment during the three months ended March 31, 2020, our disclosures are no longer presented in our consolidated financial statements and have been relocated to the “Management’s discussion and analysis of financial condition and results of operations” section in Item 7 in this annual report on Form 10-K.

Loan fees

Fees incurred in obtaining long-term financing are capitalized and classified with the corresponding debt instrument appearing on our consolidated balance sheet. Loan fees related to our unsecured senior line of credit are classified within other assets. Capitalized amounts are amortized over the term of the related loan, and the amortization is classified in interest expense in our consolidated statements of operations.

Distributions from equity method investments

We use the “nature of the distribution” approach to determine the classification within our consolidated statements of cash flows of cash distributions received from equity method investments, including our unconsolidated real estate joint ventures and equity method non-real estate investments. Under this approach, distributions are classified based on the nature of the underlying activity that generated the cash distributions. If we lack the information necessary to apply this approach in the future, we will be required to apply the “cumulative earnings” approach as an accounting change on a retrospective basis. Under the cumulative earnings approach, distributions up to the amount of cumulative equity in earnings recognized are classified as cash inflows from operating activities, and those in excess of that amount are classified as cash inflows from investing activities.

Restricted cash

We present cash and cash equivalents separately from restricted cash within our consolidated balance sheets. We include restricted cash with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown in the consolidated statements of cash flows. We provide a reconciliation between the balance sheets and statements of cash flows, as required when the balance includes more than one line item for cash, cash equivalents, and restricted cash. We also provide a disclosure of the nature of the restrictions related to material restricted cash balances.

F-21

3. INVESTMENTS IN REAL ESTATE

Our consolidated investments in real estate, including real estate assets held for sale as described in Note 18 – “Assets classified as held for sale” to our consolidated financial statements, consisted of the following as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Rental properties:
Land (related to rental properties)$3,782,182$2,550,571
Buildings and building improvements16,312,40213,364,561
Other improvements2,109,8841,508,776
Rental properties22,204,46817,423,908
Development and redevelopment of new Class A properties:
Development and redevelopment projects5,054,6323,075,453
Future development projects1,474,008738,994
Gross investments in real estate28,733,10821,238,355
Less: accumulated depreciation(3,766,758)(3,178,024)
Net investments in real estate – North America24,966,35018,060,331
Net investments in real estate – Asia14,31932,041
Investments in real estate$24,980,669$18,092,372

Acquisitions

Our real estate asset acquisitions during the year ended December 31, 2021 consisted of the following (dollars in thousands):

Square Footage
MarketNumber of PropertiesFuture DevelopmentActive Development/ RedevelopmentOperating With Future Development/RedevelopmentOperatingPurchase Price
Greater Boston101,870,9921,497,877745,209936,455$2,817,748
San Francisco Bay Area101,530,830—595,503—709,050
San Diego19951,235—927,334413,909519,710
Maryland5258,00094,256—595,38180,382
Research Triangle—1,055,000———91,000
Other434,999,768390,6751,229,7351,286,1231,251,264
Year ended December 31, 20218710,665,8251,982,8083,497,7813,231,868$5,469,154(1)

(1)Represents the aggregate contractual purchase price of our acquisitions, which differ from purchases of real estate in our consolidated statements of cash flows due to the timing of payment, closing costs, and other acquisition adjustments such as prorations of rents and expenses.

Based upon our evaluation of each acquisition, we determined that substantially all of the fair value related to each acquisition is concentrated in a single identifiable asset or a group of similar identifiable assets, or is associated with a land parcel with no operations. Accordingly, each transaction did not meet the definition of a business and therefore was accounted for as an asset acquisition. In each of these transactions, we allocated the total consideration for each acquisition to the individual tangible and intangible assets and liabilities acquired on a relative fair value basis.

During the year ended December 31, 2021, we acquired 87 properties for an aggregate purchase price of $5.5 billion. In connection with our acquisitions, we recorded in-place lease assets aggregating $306.9 million and below-market lease liabilities in which we are the lessor aggregating $120.2 million. As of December 31, 2021, the weighted-average amortization period remaining on our in-place leases and below-market leases acquired during the year ended December 31, 2021 was 8.8 years and 9.7 years, respectively, and 9.1 years in aggregate.

F-22

3. INVESTMENTS IN REAL ESTATE (continued)

In January 2022, we completed acquisitions in our key life science cluster submarkets aggregating 4.5 million SF, comprising 4.1 million RSF of future development and redevelopment opportunities and 381,760 RSF of operating space, for an aggregate purchase price of $1.2 billion.

For the discussion of the formation of our consolidated real estate joint venture, refer to the “Formation of consolidated real estate joint ventures and sales of partial interest” section in Note 4 – “Consolidated and unconsolidated real estate joint ventures” to our consolidated financial statements.

Purchase of partner’s interest in an unconsolidated real estate joint venture in March 2021

As of December 31, 2020, we had a 56.8% interest in an unconsolidated real estate joint venture that owned an operating property aggregating 80,032 RSF located at 704 Quince Orchard Road in our Gaithersburg submarket of Maryland. We accounted for this joint venture under the equity method of accounting. On March 25, 2021, we acquired the remaining 43.2% interest in this real estate joint venture for $9.4 million and fully repaid the outstanding secured loan with principal and accrued interest aggregating $14.6 million as of March 25, 2021.

As a result of this acquisition, we now own 100% of this property and consolidate its results in our consolidated financial statements. The acquired property did not meet the definition of a business and the transaction was accounted for as an asset acquisition. Under our existing accounting policy election, we follow the asset acquisition cost accumulation and allocation model. Accordingly, we did not remeasure our previously held equity interest at fair value and did not recognize a gain or loss in our consolidated statements of operations. The acquisition consideration and the carrying amount of our existing equity interest were allocated to the individual assets acquired and liabilities assumed on a relative fair value basis.

Refer to Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for more information about our evaluation of applicability of accounting guidance on asset acquisitions or business combinations.

Acquired below-market leases

The balances of acquired below-market tenant leases existing as of December 31, 2021 and 2020, and related accumulated amortization, classified in accounts payable, accrued expenses, and other liabilities in our consolidated balance sheets as of December 31, 2021 and 2020 were as follows (in thousands):

December 31,
20212020
Acquired below-market leases$579,267$477,377
Accumulated amortization(237,682)(189,302)
$341,585$288,075

For the years ended December 31, 2021, 2020, and 2019, we recognized in rental revenues approximately $57.7 million, $57.8 million, and $30.3 million, respectively, related to the amortization of acquired below-market leases existing as of the end of each respective year.

The weighted-average amortization period of the value of acquired below-market leases existing as of December 31, 2021 was approximately 5.4 years, and the estimated annual amortization of the value of acquired below-market leases as of December 31, 2021 is as follows (in thousands):

YearAmount
2022$55,813
202347,836
202437,663
202531,532
202627,761
Thereafter140,980
Total$341,585

F-23

3. INVESTMENTS IN REAL ESTATE (continued)

Acquired in-place leases

The balances of acquired in-place leases, and related accumulated amortization, classified in other assets in our consolidated balance sheets as of December 31, 2021 and 2020 were as follows (in thousands):

December 31,
20212020
Acquired in-place leases$987,213$712,380
Accumulated amortization(377,341)(250,056)
$609,872$462,324

Amortization for these intangible assets, classified in depreciation and amortization expense in our consolidated statements of operations, was approximately $146.6 million, $105.4 million, and $49.1 million for the years ended December 31, 2021, 2020, and 2019, respectively. The weighted-average amortization period of the value of acquired in-place leases was approximately 8.3 years, and the estimated annual amortization of the value of acquired in-place leases as of December 31, 2021 is as follows (in thousands):

YearAmount
2022$137,100
202397,299
202470,442
202556,701
202646,568
Thereafter201,762
Total$609,872

Sales of real estate assets and impairment charges

Sales of real estate and related gains/losses

During the three months ended September 30, 2021, we completed the sales of three office properties located in our San Francisco Bay Area and Seattle markets for an aggregate purchase price of $73.1 million and recognized a loss on sales of real estate aggregating $435 thousand.

In December 2021, we completed the sale of our 2301 5th Avenue property aggregating 197,135 RSF, located in our Lake Union submarket of Seattle, for a sales price of $118.7 million, or $602 per RSF, and recognized a gain on sale of real estate of $23.2 million.

In December 2021, we competed the sale of our entire 49.0% interest in the Menlo Gateway unconsolidated real estate joint venture, located in our Greater Stanford submarket of San Francisco Bay Area. We sold our interest for a contractual price of $397.9 million which consisted of sales price of $541.5 million less our share of debt held by the unconsolidated real estate joint venture assumed by the buyer, aggregating $143.6 million. In connection with the sale, we recognized a gain of $101.1 million, which is classified within gain on sales of real estate within our consolidated statements of operations for the year ended December 31, 2021.

The aforementioned gains and losses were classified in gain on sales of real estate within our consolidated statements of operations for the year ended December 31, 2021. For the discussion of our sales of partial interests completed during the year ended December 31, 2021, refer to the “Formation of consolidated real estate joint ventures and sales of partial interest” and “Unconsolidated real estate joint ventures” sections within Note 4 – “Consolidated and unconsolidated real estate joint ventures” to our consolidated financial statements.

F-24

3. INVESTMENTS IN REAL ESTATE (continued)

Impairment charges

During the year ended December 31, 2021, we recognized real estate asset impairments of office-related properties aggregating $52.7 million, primarily consisting of the following:

  • Impairment charge of $22.5 million during the three months ended September 30, 2021, upon classification as held for sale of an option to purchase a land parcel in our SoMa submarket for the development of an office property, to reduce the option’s carrying amount to its estimated fair value less costs to sell. We completed the sale of the option during the three months ended December 31, 2021, at no gain or loss.

  • Impairment charge of $18.6 million during the three months ended September 30, 2021, to reduce the carrying amount of a property located in a non-core submarket to its estimated fair value less costs to sell, upon our review of the current local market conditions.

  • Impairment charges aggregating $6.9 million during the six months ended June 30, 2021, to reduce the carrying amounts of three office properties located in our San Francisco Bay Area and Seattle markets to their estimated fair values less costs to sell, based on the sales price negotiated for each property during this period. We completed the sales of these properties during the three months ended September 30, 2021.

Refer to the “Impairment of long-lived assets” section within Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information.

F-25

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES

From time to time, we enter into joint venture agreements through which we own a partial interest in real estate entities that own, develop, and operate real estate properties. As of December 31, 2021, our real estate joint ventures held the following properties:

PropertyMarketSubmarketOur Ownership Interest(1)
Consolidated joint ventures*(2)**:*
50 and 60 BinneyGreater BostonCambridge/Inner Suburbs34.0%(3)
75/125 Binney StreetGreater BostonCambridge/Inner Suburbs40.0%
225 Binney StreetGreater BostonCambridge/Inner Suburbs30.0%(4)
99 Coolidge AvenueGreater BostonCambridge/Inner Suburbs75.0%
409 and 499 Illinois StreetSan Francisco Bay AreaMission Bay25.0%(3)
1500 Owens StreetSan Francisco Bay AreaMission Bay25.0%(3)
1700 Owens StreetSan Francisco Bay AreaMission Bay25.0%(3)
455 Mission Bay Boulevard SouthSan Francisco Bay AreaMission Bay25.0%(3)
Alexandria Technology Center® – Gateway(5)San Francisco Bay AreaSouth San Francisco49.9%
213 East Grand AvenueSan Francisco Bay AreaSouth San Francisco30.0%(3)
500 Forbes BoulevardSan Francisco Bay AreaSouth San Francisco10.0%
Alexandria Center® for Life Science – Millbrae StationSan Francisco Bay AreaSouth San Francisco40.3%
Alexandria Point(6)San DiegoUniversity Town Center55.0%
5200 Illumina WaySan DiegoUniversity Town Center51.0%
9625 Towne Centre DriveSan DiegoUniversity Town Center50.1%
SD Tech by Alexandria(7)San DiegoSorrento Mesa50.0%
Pacific Technology ParkSan DiegoSorrento Mesa50.0%(3)
1201 and 1208 Eastlake Avenue East and 199 East Blaine StreetSeattleLake Union30.0%
400 Dexter Avenue NorthSeattleLake Union30.0%(3)
Unconsolidated joint ventures*(2)**:*
1655 and 1725 Third StreetSan Francisco Bay AreaMission Bay10.0%
1401/1413 Research BoulevardMarylandRockville65.0%(8)
1450 Research BoulevardMarylandRockville73.2%(9)
101 West Dickman StreetMarylandBeltsville57.9%(9)

(1)Refer to the table on the next page that shows the categorization of our joint ventures under the consolidation framework.

(2)In addition to the real estate joint ventures listed, various partners hold insignificant noncontrolling interests in three other consolidated joint ventures in North America and we hold an interest in one other insignificant unconsolidated real estate joint venture in North America.

(3)Refer to the “Formation of consolidated real estate joint ventures and sales of partial interest” section within this Note 4 for additional information.

(4)225 Binney Street is owned through a tenancy in common arrangement. We directly own 26.316% of the tenancy in common and a real estate joint venture owns the remaining 73.684% of the tenancy in common. We own 5% of this real estate joint venture, resulting in an aggregate ownership of 30% of this property. We determined that we are the primary beneficiary of the real estate joint venture and we consolidate this joint venture under the variable interest model.

(5)Includes 601, 611, 651, 681, 685, 701, and 751 Gateway Boulevard in our South San Francisco submarket.

(6)Includes 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242 Campus Point Court in our University Town Center submarket.

(7)Includes 9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road and 10055 and 10065 Barnes Canyon Road in our Sorrento Mesa submarket.

(8)Represents our ownership interest; our voting interest is limited to 50%.

(9)Represent joint ventures with local real estate operators. Each of these joint ventures operates one office property which are expected to be redeveloped into office/lab. Our investments into 101 West Dickman Street and 1450 Research Boulevard joint ventures were $8.3 million and $4.0 million, respectively. The joint ventures each have a construction loan in place which is expected to fund future redevelopment cost; therefore, we expect minimal equity contributions to be required in the future. Our partners manage the day-to-day activities that most significantly affect the economic performance of each joint venture; therefore, we account for these investments under the equity method of accounting.

Our consolidation policy is described under the “Consolidation” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements. Consolidation accounting is highly technical, but its framework is primarily based on the controlling financial interests and benefits of the joint ventures.

We generally consolidate a joint venture that is a legal entity that we control (i.e., we have the power to direct the activities of the joint venture that most significantly affect its economic performance) through contractual rights, regardless of our ownership interest, and where we determine that we have benefits through the allocation of earnings or losses and fees paid to us that could be significant to the joint venture (the “VIE model”).

F-26

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES (continued)

We also generally consolidate joint ventures when we have a controlling financial interest through voting rights and where our voting interest is greater than 50% (the “voting model”). Voting interest differs from ownership interest for some joint ventures.

We account for joint ventures that do not meet the consolidation criteria under the equity method of accounting by recognizing our share of income and losses.

The table below shows the categorization of our joint ventures under the consolidation framework:

Property(1)Consolidation ModelVoting InterestConsolidation AnalysisConclusion
50 and 60 Binney StreetVIE modelNot applicable under VIE modelConsolidated
75/125 Binney Street
225 Binney StreetWe have:
99 Coolidge Avenue
409 and 499 Illinois Street
1500 Owens Street(i)The power to direct the activities of the joint venture that most significantly affect its economic performance; and
1700 Owens Street
455 Mission Bay Boulevard South
Alexandria Technology Center® – Gateway
213 East Grand Avenue
500 Forbes Boulevard(ii)Benefits that can be significant to the joint venture.
Alexandria Center® for Life Science – Millbrae Station
Alexandria Point
5200 Illumina WayTherefore, we are the primary beneficiary of each VIE
9625 Towne Centre Drive
SD Tech by Alexandria
Pacific Technology Park
1201 and 1208 Eastlake Avenue East and 199 East Blaine Street
400 Dexter Avenue North
1450 Research BoulevardWe do not control the joint venture and are therefore not the primary beneficiaryEquity method of accounting
101 West Dickman Street
1401/1413 Research BoulevardVoting modelDoes not exceed 50%Our voting interest is 50% or less
1655 and 1725 Third Street

(1) In addition to the real estate joint ventures listed, various partners hold insignificant noncontrolling interests in three other consolidated joint ventures in North America and we hold an interest in one other insignificant unconsolidated real estate joint venture in North America.

Formation of consolidated real estate joint ventures and sales of partial interest

In each of the joint ventures described below, we are contractually responsible for activities that most significantly impact the economic performance of the joint venture. In addition, our joint venture partner(s) in each of the following joint ventures lacks kick-out rights over our role as property manager. Therefore, we determined that our joint venture partner does not have a controlling financial interest and consequently each joint venture should be accounted for as a VIE. We also determined that we are the primary beneficiary of each joint venture because we are responsible for activities that most significantly impact their economic performance, and also have the obligation to absorb losses of, or the right to receive benefits from, each joint venture that could potentially be significant to the joint venture. Accordingly, we consolidate each joint venture under the variable interest model.

Refer to the “Consolidation” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information.

F-27

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES (continued)

213 East Grand Avenue

In April 2021, we sold a 70% interest in our 213 East Grand Avenue property located in our South San Francisco submarket for a sales price of $301.0 million, or $1,429 per RSF. We control the newly formed real estate joint venture and therefore continue to consolidate this property. Accordingly, we accounted for the $103.7 million difference between the consideration received and the book value of the 70% interest sold as an equity transaction, with no gain or loss recognized in earnings.

400 Dexter Avenue North

In July 2021, we sold a 70% interest in our 400 Dexter Avenue North property located in our Lake Union submarket for a sales price of $254.8 million, or $1,255 per RSF. We control the newly formed real estate joint venture and therefore continue to consolidate this property. Accordingly, we accounted for the $95.5 million difference between the consideration received and the book value of the 70% interest sold as an equity transaction, with no gain or loss recognized in earnings.

9444 Waples Street and Pacific Technology Park

In August 2021, we formed a real estate joint venture in our Sorrento Mesa submarket to own and operate our recently acquired 9444 Waples Street property and a collection of five adjacent properties owned by the joint venture partner also located on Waples Street. We own a 50% interest in this joint venture and our partner owns the remaining 50% interest. Concurrently with the formation of the joint venture, we:

(i)sold to our partner a 50% interest in our recently acquired 9444 Waples Street property, aggregating 88,380 RSF, for a sales price of $11.5 million, or $260 per RSF; and

(ii)acquired from our partner a 50% interest in Pacific Technology Park, aggregating 544,352 RSF, located at 9389, 9393, 9401, 9455, and 9477 Waples Street, for a purchase price of $85.8 million.

We control the newly formed real estate joint venture and therefore continue to consolidate 9444 Waples Street and have begun consolidating the Pacific Technology Park properties owned by the joint venture. The sales price we received for our sale of the 50% interest in 9444 Waples Street approximated 50% of the value paid for the property when initially acquired during the three months ended June 30, 2021. Therefore, there was no difference between the consideration received and the book value of the 50% interest sold.

409 and 499 Illinois Street

In October 2021, an investor acquired a 75% interest in our consolidated joint venture at 409 and 499 Illinois Street located in our Mission Bay submarket, which consisted of a 35% partial interest sold by us and a 40% interest held by our previous joint venture partner, for an aggregate sales price of $495.6 million. Our portion of the sales price was $231.0 million, representing $92.4 million of consideration in excess of the book value of our 35% interest sold. Upon completion of the sale, our ownership interest in the joint venture is 25%. We control the newly formed real estate joint venture and therefore continue to consolidate these properties. Accordingly, we accounted for the difference between the consideration received and the book value of our interest sold as an equity transaction, with no gain or loss recognized in earnings.

1500 Owens Street

In October 2021, an investor acquired a 75% interest in our consolidated joint venture at 1500 Owens Street located in our Mission Bay submarket, which consisted of a 25.1% partial interest sold by us and a 49.9% interest held by our previous joint venture partner, for an aggregate sales price of $130.5 million. Our portion of the sales price was $43.7 million, representing $21.3 million of consideration in excess of the book value of our 25.1% interest sold. Upon completion of the sale, our ownership interest in the joint venture is 25%. We control the newly formed real estate joint venture and therefore continue to consolidate this property. Accordingly, we accounted for the difference between the consideration received and the book value of our interest sold as an equity transaction, with no gain or loss recognized in earnings.

50 and 60 Binney Street

In December 2021, we formed a real estate joint venture in our Cambridge submarket and sold to our joint venture partner a 66.0% interest in our 50 and 60 Binney Street properties for a sales price of $782.3 million, or $2,226 per RSF. We control the newly formed real estate joint venture and therefore continue to consolidate these properties. Accordingly, we accounted for the $457.5 million difference between the consideration received and the book value of the 66.0% interest sold as an equity transaction, with no gain or loss recognized in earnings.

F-28

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES (continued)

1700 Owens Street and 455 Mission Bay Boulevard South

In December 2021, we formed two real estate joint ventures in our Mission Bay submarket and sold to our partner in both joint ventures a 75.0% interest in our properties at 1700 Owens Street and 455 Mission Bay Boulevard South in our Mission Bay submarket for an aggregate sales price of $381.4 million, or $1,295 per RSF. We control the newly formed real estate joint ventures and therefore continue to consolidate the properties owned by these joint ventures. Accordingly, we accounted for the $221.9 million difference between the consideration received and the aggregate book value of the 75.0% interests sold as an equity transaction, with no gain or loss recognized in earnings.

Consolidated VIEs’ balance sheet information

The table below aggregates the balance sheet information of our consolidated VIEs as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Investments in real estate$5,014,842$3,196,215
Cash and cash equivalents181,07495,565
Other assets509,281341,524
Total assets$5,705,197$3,633,304
Secured notes payable$7,991$—
Other liabilities269,605183,237
Total liabilities277,596183,237
Redeemable noncontrolling interests—1,731
Alexandria Real Estate Equities, Inc.’s share of equity2,593,5051,742,039
Noncontrolling interests’ share of equity2,834,0961,706,297
Total liabilities and equity$5,705,197$3,633,304

In determining whether to aggregate the balance sheet information of consolidated VIEs, we considered the similarity of each VIE, including the primary purpose of these entities to own, manage, operate, and lease real estate properties owned by the VIEs, and the similar nature of our involvement in each VIE as a managing member. Due to the similarity of the characteristics, we present the balance sheet information of these entities on an aggregated basis. None of our consolidated VIEs’ assets have restrictions that limit their use to settle specific obligations of the VIE. There are no creditors or other partners of our consolidated VIEs that have recourse to our general credit, and our maximum exposure to our consolidated VIEs is limited to our variable interests in each VIE, except for our 99 Coolidge Avenue joint venture in which the VIE’s construction loan is guaranteed by us. For additional information, refer to Note 10 – “Secured and unsecured senior debt” to our consolidated financial statements.

F-29

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES (continued)

Unconsolidated real estate joint ventures

Our maximum exposure to our unconsolidated VIEs is limited to our investment in each VIE. Our investments in unconsolidated real estate joint ventures, accounted for under the equity method of accounting as presented in our consolidated balance sheets of December 31, 2021 and 2020, consisted of the following (in thousands):

December 31,
Property20212020
Menlo Gateway(1)$—$300,622
1655 and 1725 Third Street14,03414,939
1450 Research Boulevard4,455—
101 West Dickman Street8,481—
704 Quince Orchard Road—4,961
Other11,51311,827
$38,483$332,349

(1)During the three months ended December 31, 2021, we sold our entire 49.0% equity interest in this unconsolidated real estate joint venture.

704 Quince Orchard Road

During the year ended December 31, 2021, we acquired our partner’s ownership interest in our unconsolidated real estate joint venture that holds our property located at 704 Quince Orchard Road. For additional information, refer to the “Purchase of partner’s interest in an unconsolidated real estate joint venture in March 2021” subsection of the “Acquisitions” section in Note 3 – “Investments in real estate” to our consolidated financial statements.

Menlo Gateway

In December 2021, we sold our entire 49.0% equity interest in our unconsolidated real estate joint venture at Menlo Gateway, aggregating 772,983 RSF of tech office space located in our Greater Stanford submarket of the San Francisco Bay Area for a sales price of $541.5 million, or $1,430 per RSF. We received $397.9 million in proceeds, which consisted of a sales price of $541.5 million less our share of debt held by the unconsolidated real estate joint venture assumed by the buyer, aggregating $143.6 million. In connection with the sale, we recognized a gain of $101.1 million, which is classified within gain on sales of real estate within our consolidated statements of operations for the year ended December 31, 2021.

1401/1413 Research Boulevard

In January 2015, we formed a joint venture with a local retail developer and operator by contributing a land parcel located in our Rockville submarket of Maryland. The joint venture developed a retail shopping center aggregating approximately 90,000 RSF, which was primarily funded by a construction loan that is non-recourse to us. Since its formation, we accounted for this investment under the equity method of accounting as we do not have a controlling interest.

In March 2020, as a result of the impact of the COVID-19 pandemic, we evaluated the recoverability of our investment and recognized a $7.6 million impairment charge to lower the carrying amount of our investment balance to zero and eliminated this investment from our consolidated balance sheet. We continue to hold our economic interest in this joint venture. However, as the investment balance was carried at zero dollars, we discontinued applying the equity method recognition of losses in excess of our capital commitments to the joint venture.

The equity method of accounting continues to remain suspended until a point where either (i) the joint venture accumulates operating profits in excess of losses accumulated or (ii) additional financial support is contributed by us to the joint venture.

In June 2021, as a result of improving economic conditions for this retail center, we contributed capital aggregating $578 thousand to the joint venture to become current with required capital contributions and maintain our 65.0% equity interest in this joint venture. This contribution increased our investment in the joint venture, but this was offset by the recognition of our share of operating losses of the joint venture that occurred while our equity method accounting was suspended. In June 2021, concurrently with the additional financial support contributed to the joint venture, we recognized equity in losses of unconsolidated real estate joint ventures equal to the $578 thousand, resulting in a carrying amount of our investment in the joint venture of zero dollars as of June 30, 2021.

F-30

4. CONSOLIDATED AND UNCONSOLIDATED REAL ESTATE JOINT VENTURES (continued)

101 West Dickman Street and 1450 Research Boulevard

In October 2021, we formed a real estate joint venture with two partners holding a 135,423 RSF property located at 101 West Dickman Street in our Maryland market, in which we acquired a 57.9% ownership interest for $8.3 million. In addition, in December 2021, we formed a real estate joint venture with a partner holding a 42,679 RSF property located at 1450 Research Boulevard in our Maryland market, in which we acquired a 73.2% ownership interest for $4.0 million.

Each of these joint ventures operates one office property which are expected to be redeveloped into office/lab. The joint ventures have construction loans in place which are expected to fund future redevelopment costs and therefore we expect minimal additional future equity contributions from us to be required.

Our joint venture partners manage the day-to-day activities that most significantly affect the economic performance of each joint venture. Therefore, we account for our investments under the equity method of accounting.

The following table presents key terms related to our unconsolidated real estate joint ventures’ secured loans as of December 31, 2021 (dollars in thousands):

Unconsolidated Joint VentureOur ShareMaturity DateStated RateInterest Rate(1)Aggregate Commitment at 100%Debt Balance at 100%(2)
1401/1413 Research Boulevard65.0%12/23/242.70%3.14%$28,500$28,124
1655 and 1725 Third Street10.0%3/10/254.50%4.57%600,000598,657
101 West Dickman Street57.9%11/10/26SOFR + 1.95%(3)2.81%26,7509,947
1450 Research Boulevard73.2%12/10/26SOFR + 1.95%(3)N/A13,000—
$668,250$636,728

(1)Includes interest expense and amortization of loan fees.

(2)Represents outstanding principal, net of unamortized deferred financing costs, as of December 31, 2021.

(3)This loan is subject to a fixed SOFR floor rate of 0.75%.

F-31

5. LEASES

We are subject to the lease accounting standard that sets principles for the recognition, measurement, presentation, and disclosure of leases for both parties to a lease agreement (i.e., lessees and lessors).

As a lessor, we are required to disclose, among other things, the following:

  • A description of the nature of leases, including terms for any variable payments, options to extend or terminate, and options to purchase the underlying asset;

  • Tabular presentation of undiscounted cash flows to be received over the next five years and thereafter separately for operating leases and direct financing leases;

  • The amount of lease income and its location on the statements of operations;

  • Income classified separately for operating leases and direct financing leases; and

  • Our risk management strategy to mitigate declines in residual value of the leased assets.

As a lessee, we are required to disclose, among other things, the following:

  • A description of the nature of leases, including terms for any variable payments, options to extend or terminate, and options to purchase the underlying asset;

  • The amounts of lease liabilities and corresponding right-of-use assets and their respective locations in the balance sheet;

  • The weighted-average remaining lease term and weighted-average discount rate of leases;

  • Tabular presentation of undiscounted cash flows of our remaining lease payment obligations over the next five years and thereafter; and

  • Total lease costs, including cash paid, amounts expensed, and amounts capitalized.

Refer to the “Lease accounting” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information.

Leases in which we are the lessor

As of December 31, 2021, we had 414 properties aggregating 38.8 million operating RSF located in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. We focus on developing Class A properties in AAA innovation cluster locations, which we consider to be highly desirable for tenancy by life science, agtech, and technology entities. Such locations are generally characterized by high barriers to entry for new landlords, high barriers to exit for tenants, and a limited supply of available space. As of December 31, 2021, all leases in which we are the lessor were classified as operating leases with the exception of one direct financing lease and two sales-type leases. Our operating, direct financing, and sales-type leases are described below.

Operating leases

As of December 31, 2021, our 414 properties were subject to operating lease agreements. Two of these properties, representing two land parcels, are subject to lease agreements that each contain an option for the lessee to purchase the underlying asset from us at fair market value during each of the 30-day periods commencing on the dates that are 15 years, 30 years, and 74.5 years after the rent commencement date of October 1, 2017. The remaining lease term related to each of the two land parcels is 70.9 years. Our leases generally contain options to extend lease terms at prevailing market rates at the time of expiration. Certain operating leases contain early termination options that require advance notification and payment of a penalty, which in most cases is substantial enough to be deemed economically disadvantageous by a tenant to exercise. Future lease payments to be received under the terms of our operating lease agreements, excluding expense reimbursements, in effect as of December 31, 2021 are outlined in the table below (in thousands):

YearAmount
2022$1,539,355
20231,623,950
20241,600,255
20251,530,227
20261,464,150
Thereafter10,131,628
Total$17,889,565

Refer to Note 3 – “Investments in real estate” to our consolidated financial statements for additional information about our owned real estate assets, which are the underlying assets under our operating leases.

F-32

5. LEASES (continued)

Direct financing and sales-type leases

As of December 31, 2021, we had one direct financing lease agreement, with a net investment balance of $38.6 million, for a parking structure with a remaining lease term of 70.9 years. The lessee has an option to purchase the underlying asset at fair market value during each of the 30-day periods commencing on the dates that are 15 years, 30 years, and 74.5 years after the rent commencement date of October 1, 2017.

During the year ended December 31, 2021, we acquired two sales-type ground lease agreements. As of December 31, 2021, these leases had a net investment balance of $32.1 million and a weighted-average remaining lease term of 87.9 years. Upon recognition of the two sales-type ground leases during the year ended December 31, 2021, the present value of future lease payments approximated our carrying value of the leased assets; therefore, no profit or loss was recognized in connection with these leases.

The components of our aggregate net investment in our direct financing and sales-type leases as of December 31, 2021 and 2020, are summarized in the table below (in thousands):

December 31,
20212020
Gross investment in direct financing and sales-type leases$403,388$258,751
Add: estimated unguaranteed residual value of the underlying assets31,839—
Less: unearned income on direct financing lease(215,557)(218,072)
Less: effect of discounting on sales-type leases(146,175)—
Less: allowance for credit losses(2,839)(2,839)
Net investment in direct financing and sales-type leases$70,656$37,840

As of December 31, 2021, our estimated credit loss related to our direct financing lease was $2.8 million. No adjustment to the estimated credit loss balance was required during the year ended December 31, 2021.

We determined our two sales-type leases were not financial assets purchased with credit deterioration, and as such did not recognize an initial credit loss reserve, based on our experience with leases that included similar collateral and tenant creditworthiness. At December 31, 2021, we reassessed the collectability of these leases and determined that no credit loss adjustment was necessary. For further details, refer to the “Allowance for credit losses” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements.

F-33

5. LEASES (continued)

Future lease payments to be received under the terms of our direct financing and sales-type leases as of December 31, 2021 are outlined in the table below, in aggregate (in thousands):

YearTotal
2022$3,066
20233,120
20243,176
20253,371
20263,459
Thereafter387,196
Total$403,388

Income from rentals

Our total income from rentals includes revenue related to agreements for the rental of our real estate, which primarily includes revenues subject to the lease accounting standard and the revenue recognition accounting standard as shown below (in thousands):

Year Ended December 31,
202120202019
Income from rentals:
Revenues subject to the lease accounting standard:
Operating leases$2,081,362$1,854,427$1,465,692
Direct financing and sales-type leases3,4892,4692,421
Revenues subject to the lease accounting standard2,084,8511,856,8961,468,113
Revenues subject to the revenue recognition accounting standard23,39821,31248,751
Income from rentals$2,108,249$1,878,208$1,516,864

Our revenues that are subject to the revenue recognition accounting standard and are classified in income from rentals consist primarily of short-term parking revenues that are not considered lease revenues under the lease accounting standard. Refer to the “Revenues” and “Recognition of revenue arising from contracts with customers” sections in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information.

Deferred leasing costs

The following table summarizes our deferred leasing costs as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Deferred leasing costs$857,414$679,300
Accumulated amortization(454,516)(406,627)
Deferred leasing costs, net$402,898$272,673

Residual value risk management strategy

Our leases do not have guarantees of residual value on the underlying assets. We manage risk associated with the residual value of our leased assets by (i) evaluating each potential acquisition of real estate to determine whether it meets our business objective to invest primarily in high-demand markets with limited supply of available space, (ii) directly managing our leased properties, conducting frequent property inspections, proactively addressing potential maintenance issues before they arise, and timely resolving any occurring issues, (iii) carefully selecting our tenants and monitoring their credit quality throughout their respective lease terms, and (iv) focusing on making continuous improvements to our sustainability efforts and achievement of our sustainability goals for ground-up development of new buildings, which are targeting Gold or Platinum LEED® certification. Our environmentally focused design decisions, careful selection of construction materials, and continuous monitoring of our properties throughout their lives are expected to promote the durability of building infrastructure and enhance residual value of our properties.

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5. LEASES (continued)

Leases in which we are the lessee

Operating lease agreements

We have operating lease agreements in which we are the lessee consisting of ground and office leases. Certain of these leases have options to extend or terminate the contract terms upon meeting certain criteria. There are no notable restrictions or covenants imposed by the leases, nor guarantees of residual value.

We recognize a right-of-use asset, which is classified within other assets in our consolidated balance sheets, and a related liability, which is classified within accounts payable, accrued expenses, and other liabilities in our consolidated balance sheets, to account for our future obligations under ground and office lease arrangements in which we are the lessee. Refer to the “Lessee accounting” subsection of the “Lease accounting” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements.

As of December 31, 2021, the present value of the remaining contractual payments aggregating $953.3 million under our operating lease agreements, including our extension options that we are reasonably certain to exercise, was $434.7 million. Our corresponding operating lease right-of-use assets, adjusted for initial direct leasing costs and other consideration exchanged with the landlord prior to the commencement of the lease, aggregated $474.3 million. As of December 31, 2021, the weighted-average remaining lease term of operating leases in which we are the lessee was approximately 42 years, and the weighted-average discount rate was 4.57%. The weighted-average discount rate is based on the incremental borrowing rate estimated for each lease, which is the interest rate that we estimate we would have to pay to borrow on a collateralized basis over a similar term for an amount equal to the lease payments.

Ground lease obligations as of December 31, 2021, included leases for 39 of our properties, which accounted for approximately 9% of our total number of properties. Excluding one ground lease that expires in 2036 related to one operating property with a net book value of $6.9 million as of December 31, 2021, our ground lease obligations have remaining lease terms ranging from approximately 32 years to 93 years, including extension options which we are reasonably certain to exercise.

The reconciliation of future lease payments, under noncancelable operating ground and office leases in which we are the lessee, to the operating lease liability reflected in our consolidated balance sheet as of December 31, 2021 is presented in the table below (in thousands):

YearTotal
2022$48,499
202322,245
202422,478
202522,500
202622,501
Thereafter815,064
Total future payments under our operating leases in which we are the lessee953,287
Effect of discounting(518,542)
Operating lease liability$434,745

Lessee operating costs

Operating lease costs relate to our ground and office leases in which we are the lessee. Ground leases generally require fixed annual rent payments and may also include escalation clauses and renewal options. Our operating lease obligations related to our office leases have remaining terms of up to 14 years, exclusive of extension options. For the years ended December 31, 2021, 2020, and 2019, our costs for operating leases in which we are the lessee were as follows (in thousands):

Year Ended December 31,
202120202019
Gross operating lease costs$28,598$23,518$19,740
Capitalized lease costs(3,167)(3,529)(1,452)
Expenses for operating leases in which we are the lessee$25,431$19,989$18,288

For the years ended December 31, 2021, 2020, and 2019, amounts paid and classified as operating activities in our consolidated statements of cash flows for leases in which we are the lessee, were $24.7 million, $20.8 million, and $17.7 million, respectively.

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6. CASH, CASH EQUIVALENTS, AND RESTRICTED CASH

Cash, cash equivalents, and restricted cash consisted of the following as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Cash and cash equivalents$361,348$568,532
Restricted cash:
Funds held in trust under the terms of certain secured notes payable17,26417,256
Funds held in escrow related to construction projects and investing activities30,0004,580
Other6,6157,337
53,87929,173
Total$415,227$597,705

F-36

7. INVESTMENTS

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. Our accounting for non-real estate investments is summarized below. Refer to the “Investments” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information.

Investments in publicly traded companies

Our investments in publicly traded companies are classified as investments with readily determinable fair values and are presented at fair value in our consolidated balance sheets, with changes in fair value classified in investment income in our consolidated statements of operations.

Investments in privately held companies

Our investments in privately held entities consist of (i) investments in privately held entities that report NAV, and (ii) investments in privately held entities that do not report NAV. These investments are accounted for as follows:

Investments in privately held entities that report NAV

Investments in entities that report NAV, such as our privately held investments in limited partnerships, are presented at fair value using NAV as a practical expedient, with changes in fair value recognized in net income. We use NAV reported by limited partnerships generally without adjustment, unless we are aware of information indicating that the NAV reported by a limited partnership does not accurately reflect the fair value of the investment at our reporting date.

Investments in privately held entities that do not report NAV

Investments in privately held entities that do not report NAV are carried at cost, adjusted for observable price changes and impairments, with changes recognized in net income. An observable price arises from an orderly transaction for an identical or similar investment of the same issuer. Observable price changes result from, among other things, equity transactions of the same issuer executed during the reporting period, including subsequent equity offerings or other reported equity transactions related to the same issuer. To determine whether these transactions are indicative of an observable price change, we evaluate, among other factors, whether these transactions have similar rights and obligations, including voting rights, distribution preferences, and conversion rights to the investments we hold.

These investments continue to be evaluated on the basis of a qualitative assessment for indicators of impairment by utilizing the monitoring criteria described in the “Investments” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements, and by monitoring the presence of the following impairment indicators:

(i)a significant deterioration in the earnings performance, credit rating, asset quality, or business prospects of the investee;

(ii)a significant adverse change in the regulatory, economic, or technological environment of the investee;

(iii)a significant adverse change in the general market condition, including the research and development of technology and products that the investee is bringing or attempting to bring to the market;

(iv)significant concerns about the investee’s ability to continue as a going concern; and/or

(v)a decision by investors to cease providing support or reduce their financial commitment to the investee.

If such indicators are present, we are required to estimate the investment’s fair value and immediately recognize an impairment charge in an amount equal to the investment’s carrying value in excess of its estimated fair value.

Investments accounted for under the equity method

We account for our investments under the equity method whenever we are deemed to have significant influence over the investee’s operating and financial policies. Under the equity method of accounting, we initially recognize our investment at cost and subsequently adjust the carrying amount of the investment for our share of the investee’s earnings or losses, distributions received, and other-than-temporary impairments. Refer to the “Investments” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements for additional information on the criteria used to determine whether an investment should be accounted for under the equity method, and for our impairment assessment of our equity method investments.

As of December 31, 2021, we had six investments in privately held entities aggregating $71.6 million accounted for under the equity method. Our ownership interest in each of our investments accounted for under the equity method of accounting is less than 20%. Our equity in earnings or losses of our equity method investees is recognized in each period for which these earnings or losses are reported by the investee, and is classified within investment income in our consolidated statements of operations.

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7. INVESTMENTS (continued)

Investment income/loss recognition and classification

We classify unrealized and realized gains and losses on our investments within investment income in our consolidated statements of operations. Unrealized gains and losses represent:

(i)changes in fair value for investments in publicly traded companies;

(ii)changes in NAV as a practical expedient to estimate fair value for investments in privately held entities that report NAV per share;

(iii)observable price changes for investments in privately held entities that do not report NAV per share; and

(iv)our share of unrealized gains or losses reported by our equity method investees.

Realized gains and losses on our investments represent the difference between proceeds received upon disposition of investments and their historical or adjusted cost. For our equity method investments, realized gains and losses represent our share of realized gains or losses reported by the investee. Impairments are realized losses, which result in an adjusted cost, and represent charges to reduce the carrying values of investments in privately held entities that do not report NAV per share and equity method investments, if impairments are deemed other than temporary to their estimated fair value.

The following tables summarize our investments as of December 31, 2021 and 2020 (in thousands):

December 31, 2021
CostUnrealized Gains (Losses)Carrying Amount
Publicly traded companies$203,290$280,527$483,817
Entities that report NAV385,692444,172829,864
Entities that do not report NAV:
Entities with observable price changes56,25772,974129,231
Entities without observable price changes362,064—362,064
Investments accounted for under the equity methodN/AN/A71,588
Total investments$1,007,303$797,6731,876,564
December 31, 2020
CostUnrealized Gains (Losses)Carrying Amount
Publicly traded companies$208,754$351,076$559,830
Entities that report NAV334,341327,741662,082
Entities that do not report NAV:
Entities with observable price changes47,54596,859144,404
Entities without observable price changes244,798—244,798
Total investments$835,438$775,676$1,611,114

Cumulative gains and losses (realized and unrealized) on investments in privately held entities that do not report NAV still held as of December 31, 2021 aggregated to a gain of $31.2 million, which consisted of upward adjustments of $74.3 million, downward adjustments of $1.3 million, and impairments of $41.8 million.

Our investment income for the years ended December 31, 2021, 2020, and 2019 consisted of the following (in thousands):

Year Ended December 31,
202120202019
Realized gains$215,845$47,288$33,158
Unrealized gains43,632374,033161,489
Investment income$259,477$421,321$194,647

During the year ended December 31, 2021, gains and losses on investments in privately held entities that do not report NAV still held at December 31, 2021 aggregated to a loss of $33.3 million, which consisted of upward adjustments of $32.7 million and downward adjustments primarily related to observable prices changes aggregating $66.0 million.

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7. INVESTMENTS (continued)

During the year ended December 31, 2020, gains and losses on investments in privately held entities that do not report NAV still held at December 31, 2020 aggregated to a gain of $3.1 million, which consisted of upward adjustments of $36.7 million and downward adjustments and impairments of $33.6 million.

During the year ended December 31, 2019, gains and losses on investments in privately held entities that do not report NAV still held at December 31, 2019 aggregated to a loss of $12.7 million, which consisted of upward adjustments of $5.2 million and downward adjustments and impairments of $18.0 million.

Unrealized gains related to investments still held (excluding investments accounted for under the equity method of accounting) at December 31, 2021, 2020, and 2019 aggregated $109.4 million, $392.7 million, and $184.6 million during the years ended December 31, 2021, 2020, and 2019, respectively.

Our investment income for the year ended December 31, 2021 also included $19.7 million of equity in earnings of our equity method investments.

Commitments on investments in privately held entities that report NAV

We are committed to funding approximately $358.0 million for all investments in privately held entities that report NAV. Our funding commitments expire at various dates over the next 11 years, with a weighted-average expiration of 9.0 years as of December 31, 2021. These investments are not redeemable by us, but we may receive distributions from these investments throughout their terms. Our investments in privately held entities that report NAV generally have expected initial terms in excess of 10 years. The weighted-average remaining term during which these investments are expected to be liquidated was 5.2 years as of December 31, 2021.

8. OTHER ASSETS

The following table summarizes the components of other assets as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Acquired in-place leases$609,872$462,324
Deferred compensation plan38,93731,057
Deferred financing costs – unsecured senior line of credit19,29424,124
Deposits176,07713,861
Furniture, fixtures, and equipment26,42931,130
Net investment in direct financing and sales-type leases70,65637,840
Notes receivable13,0883,424
Operating lease right-of-use asset474,299335,920
Other assets53,98530,620
Prepaid expenses24,80667,667
Property, plant, and equipment151,375153,614
Total$1,658,818$1,191,581

F-39

9. FAIR VALUE MEASUREMENTS

We provide fair value information about all financial instruments for which it is practicable to estimate fair value. We measure and disclose the estimated fair value of financial assets and liabilities by utilizing a fair value hierarchy that distinguishes between data obtained from sources independent of the reporting entity and the reporting entity’s own assumptions about market participant assumptions. This hierarchy consists of three broad levels, as follows: (i) quoted prices in active markets for identical assets or liabilities (Level 1), (ii) significant other observable inputs (Level 2), and (iii) significant unobservable inputs (Level 3). Significant other observable inputs can include quoted prices for similar assets or liabilities in active markets, as well as inputs that are observable for the asset or liability, such as interest rates, foreign exchange rates, and yield curves. Significant unobservable inputs are typically based on an entity’s own assumptions, since there is little, if any, related market activity. In instances in which the determination of the fair value measurement is based on inputs from different levels of the fair value hierarchy, the level in the fair value hierarchy within which the entire fair value measurement falls is based on the lowest level of input that is significant to the fair value measurement in its entirety. Our assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset or liability.

Assets and liabilities measured at fair value on a recurring basis

The following table sets forth the assets that we measure at fair value on a recurring basis by level in the fair value hierarchy (in thousands). There were no liabilities measured at fair value on a recurring basis as of December 31, 2021 and 2020. In addition, there were no transfers of assets measured at fair value on a recurring basis to or from Level 3 in the fair value hierarchy during the year ended December 31, 2021.

Fair Value Measurement Using
DescriptionTotalQuoted Prices in Active Markets for Identical Assets (Level 1)Significant Other Observable Inputs (Level 2)Significant Unobservable Inputs (Level 3)
Investments in publicly traded companies:
As of December 31, 2021$483,817$483,817$—$—
As of December 31, 2020$559,830$559,830$—$—

Our investments in publicly traded companies represent investments with readily determinable fair values, and are carried at fair value, with changes in fair value classified in net income. We also hold investments in privately held entities, which consist of (i) investments that report NAV, and (ii) investments that do not report NAV, as further described below.

Our investments in privately held entities that report NAV, such as our privately held investments in limited partnerships, are carried at fair value using NAV as a practical expedient, with changes in fair value classified in net income. As of December 31, 2021 and 2020, the carrying values of investments in privately held entities that report NAV aggregated $829.9 million and $662.1 million, respectively. These investments are excluded from the fair value hierarchy above as required by the fair value accounting standards. We estimate the fair value of each of our investments in limited partnerships based on the most recent NAV reported by each limited partnership. As a result, the determination of fair values of our investments in privately held entities that report NAV generally does not involve significant estimates, assumptions, or judgments.

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9. FAIR VALUE MEASUREMENTS (continued)

Assets and liabilities measured at fair value on a nonrecurring basis

The following table sets forth the assets measured at fair value on a nonrecurring basis by level within the fair value hierarchy as of December 31, 2021 and 2020 (in thousands). These investments were measured at various times during the period from January 1, 2018 to December 31, 2021.

Fair Value Measurement Using
DescriptionTotalQuoted Prices in Active Markets for Identical Assets (Level 1)Significant Other Observable Inputs (Level 2)Significant Unobservable Inputs (Level 3)
Investments in privately held entities that do not report NAV
As of December 31, 2021$138,011$—$129,231(1)$8,780(2)
As of December 31, 2020$157,871$—$144,404$13,467

(1)This balance represents the total carrying amount of our equity investments in privately held entities with observable price changes, included in our total investments balance of $1.9 billion in our consolidated balance sheets as of December 31, 2021. For more information, refer to Note 7 – “Investments” to our consolidated financial statements.

(2)This amount is included in the $362.1 million balance of investments in privately held entities without observable price changes disclosed in Note 7 – “Investments” to our consolidated financial statements and represents the carrying amount of investments in privately held entities that do not report NAV for which impairments have been recognized in accordance with the measurement alternative guidance described within the “Investments” section in Note 2 – “Summary of significant accounting policies” to our consolidated financial statements.

Our investments in privately held entities that do not report NAV are measured at cost, adjusted for observable price changes and impairments, with changes recognized in net income. These investments are adjusted based on the observable price changes in orderly transactions for the identical or similar investment of the same issuer. Further adjustments are not made until another observable transaction occurs. Therefore, the determination of fair values of our investments in privately held entities that do not report NAV does not involve significant estimates and assumptions or subjective and complex judgments.

We also subject our investments in privately held entities that do not report NAV to a qualitative assessment for indicators of impairment. If indicators of impairment are present, we are required to estimate the investment’s fair value and immediately recognize an impairment charge in an amount equal to the investment’s carrying value in excess of its estimated fair value.

The estimates of fair value typically incorporate valuation techniques that include an income approach reflecting a discounted cash flow analysis, and a market approach that includes a comparative analysis of acquisition multiples and pricing multiples generated by market participants. In certain instances, we may use multiple valuation techniques for a particular investment and estimate its fair value based on an average of multiple valuation results.

Our real estate assets classified as held for sale are measured at fair value less cost to sell, with changes recognized in net income. We evaluate these assets utilizing an agreed-upon contractual sales price and available comparable market information. If this information is not available, we use estimated replacement costs or estimated cash flow projections that utilize appropriate discount and capitalization rates.

Refer to Note 4 – “Consolidated and unconsolidated real estate joint ventures,” Note 7 – “Investments,” and Note 18 – “Assets classified as held for sale” to our consolidated financial statements for additional information.

The carrying values of cash and cash equivalents, restricted cash, tenant receivables, deposits, notes receivable, accounts payable, accrued expenses, and other short-term liabilities approximate their fair value.

The fair values of our secured notes payable, unsecured senior notes payable, and the amounts outstanding on our unsecured senior line of credit, and commercial paper program were estimated using widely accepted valuation techniques, including discounted cash flow analyses using significant other observable inputs such as available market information on discount and borrowing rates with similar terms, maturities, and credit ratings. Because the valuations of our financial instruments are based on these types of estimates, the actual fair value of our financial instruments may differ materially if our estimates do not prove to be accurate. Additionally, the use of different market assumptions or estimation methods may have a material effect on the estimated fair value amounts.

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9. FAIR VALUE MEASUREMENTS (continued)

As of December 31, 2021 and 2020, the book and estimated fair values of our secured notes payable, unsecured senior notes payable, and amounts outstanding under our unsecured senior line of credit and commercial paper program, including the level within the fair value hierarchy for which the estimates were derived, were as follows (in thousands):

December 31, 2021
Book ValueFair Value HierarchyEstimated Fair Value
Quoted Prices in Active Markets for Identical Assets (Level 1)Significant Other Observable Inputs (Level 2)Significant Unobservable Inputs (Level 3)
Liabilities:
Secured notes payable$205,198$—$214,097$—$214,097
Unsecured senior notes payable$8,316,678$—$8,995,913$—$8,995,913
Unsecured senior line of credit$—$—$—$—$—
Commercial paper program$269,990$—$269,994$—$269,994
December 31, 2020
Book ValueFair Value HierarchyEstimated Fair Value
Quoted Prices in Active Markets for Identical Assets (Level 1)Significant Other Observable Inputs (Level 2)Significant Unobservable Inputs (Level 3)
Liabilities:
Secured notes payable$230,925$—$249,782$—$249,782
Unsecured senior notes payable$7,232,370$—$8,447,845$—$8,447,845
Unsecured senior line of credit$—$—$—$—$—
Commercial paper program$99,991$—$99,998$—$99,998

F-42

10. SECURED AND UNSECURED SENIOR DEBT

The following table summarizes our outstanding indebtedness and respective principal payments as of December 31, 2021 (dollars in thousands):

Stated RateInterest Rate (1)Maturity Date (2)Principal Payments Remaining for the Periods Ending December 31,Unamortized (Deferred Financing Cost), (Discount) Premium
Debt20222023202420252026ThereafterPrincipalTotal
Secured notes payable
Greater Boston4.82%3.40%2/6/24$3,564$3,742$183,527$—$—$—$190,8335,696$196,529
Greater Boston(3)SOFR + 2.70%3.1011/19/26————10,002—10,002(2,011)7,991
San Francisco Bay Area6.50%6.507/1/362830323436518678—678
Secured debt weighted average interest rate/subtotal4.74%3.403,5923,772183,5593410,038518201,5133,685205,198
Commercial paper program(4)0.29%(4)0.29(4)(4)(4)———270,000(4)—270,000(10)269,990
Unsecured senior line of creditL+0.815%(5)N/A1/6/26—————————
Unsecured senior notes payable3.45%3.624/30/25———600,000——600,000(2,934)597,066
Unsecured senior notes payable4.30%4.501/15/26————300,000—300,000(1,987)298,013
Unsecured senior notes payable – green bond3.80%3.964/15/26————350,000—350,000(2,116)347,884
Unsecured senior notes payable3.95%4.131/15/27—————350,000350,000(2,570)347,430
Unsecured senior notes payable3.95%4.071/15/28—————425,000425,000(2,569)422,431
Unsecured senior notes payable4.50%4.607/30/29—————300,000300,000(1,689)298,311
Unsecured senior notes payable2.75%2.8712/15/29—————400,000400,000(3,284)396,716
Unsecured senior notes payable4.70%4.817/1/30—————450,000450,000(3,167)446,833
Unsecured senior notes payable4.90%5.0512/15/30—————700,000700,000(7,067)692,933
Unsecured senior notes payable3.375%3.488/15/31—————750,000750,000(6,264)743,736
Unsecured senior notes payable – green bond2.00%2.125/18/32—————900,000900,000(9,712)890,288
Unsecured senior notes payable1.875%1.972/1/33—————1,000,0001,000,000(9,701)990,299
Unsecured senior notes payable4.85%4.934/15/49—————300,000300,000(3,217)296,783
Unsecured senior notes payable4.00%3.912/1/50—————700,000700,00010,320710,320
Unsecured senior notes payable3.00%3.085/18/51—————850,000850,000(12,365)837,635
Unsecured debt weighted average interest rate/subtotal3.44———600,000920,0007,125,0008,645,000(58,332)8,586,668
Weighted-average interest rate/total3.44%$3,592$3,772$183,559$600,034$930,038$7,125,518$8,846,513$(54,647)$8,791,866

(1)Represents the weighted-average interest rate as of the end of the applicable period, including amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)Reflects any extension options that we control.

(3)Relates to our real estate joint venture at 99 Coolidge Avenue, of which we own 75.0%. As of December 31, 2021, this joint venture has a $185.3 million availability under the existing lender commitments. The interest rate shall be reduced from SOFR+2.70% to SOFR+2.10% over time upon the completion of certain leasing, construction, and financial covenant milestones.

(4)Refer to footnote 2 on the next page.

(5)During the year ended December 31, 2020, we achieved certain sustainability measures, as described in our unsecured senior line of credit agreement, which reduced the borrowing rate by one basis point for a one-year period.

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10. SECURED AND UNSECURED SENIOR DEBT (continued)

The following table summarizes our secured and unsecured senior debt and amounts outstanding under our commercial paper program as of December 31, 2021 (dollars in thousands):

Fixed-Rate DebtVariable-Rate DebtWeighted-Average
Interest Rate(1)Remaining Term (in years)
TotalPercentage
Secured notes payable$195,196$10,002$205,1982.3%3.40%2.2
Unsecured senior notes payable8,316,678—8,316,67894.63.5412.6
Unsecured senior line of credit————N/A4.0
Commercial paper program—269,990269,9903.10.29(2)
Total/weighted average$8,511,874$279,992$8,791,866100.0%3.44%12.1(2)
Percentage of total debt97%3%100%

(1)Represents the weighted-average interest rate as of the end of the applicable period, including expense/income related to the amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)The commercial paper notes bear interest at short-term fixed rates and can generally be issued with a maturity of 30 days or less and with a maximum maturity of 397 days from the date of issuance. Borrowings under the program are used to fund short-term capital needs and are backed by our unsecured senior line of credit. The commercial paper outstanding as of December 31, 2021 matured on January 18, 2022. In the event we are unable to issue commercial paper notes or refinance outstanding borrowings under terms equal to or more favorable than those under our unsecured senior line of credit, we expect to borrow under the unsecured senior line of credit at L+0.815%. As such, we calculate the weighted-average remaining term of our commercial paper by using the maturity date of our unsecured senior line of credit. Using the maturity date of our outstanding commercial paper, the consolidated weighted-average maturity of our debt is 11.9 years as of December 31, 2021. The commercial paper notes sold during the three months ended December 31, 2021 were issued at a weighted-average yield to maturity of 0.24% and had a weighted-average maturity term of 12 days.

Unsecured senior notes payable

In February 2021, we opportunistically issued $1.75 billion of unsecured senior notes payable with a weighted-average interest rate of 2.49% and a weighted-average maturity of 20.4 years. The unsecured senior notes consisted of $900.0 million of 2.00% unsecured senior notes due 2032 (“2.00% Unsecured Senior Notes”) and $850.0 million of 3.00% unsecured senior notes due 2051 (“3.00% Unsecured Senior Notes”). The proceeds from our 2.00% Unsecured Senior Notes are expected to be allocated to eligible green projects and were initially used to refinance $650.0 million of our 4.00% unsecured senior notes payable due in 2024 pursuant to a partial cash tender offer completed on February 10, 2021, and a subsequent call for redemption for the remaining outstanding amounts that settled on March 12, 2021. As a result of this refinancing, we recognized a loss on early extinguishment of debt of $67.2 million, including the write-off of unamortized loan fees and premiums.

$1.5 billion co****mmercial paper program

Our commercial paper program provides us with the ability to issue up to $1.5 billion of commercial paper with a maturity of generally 30 days or less and with a maximum maturity of 397 days from the date of issuance. Our commercial paper program is backed by our unsecured senior line of credit, and at all times we expect to retain a minimum undrawn amount of borrowing capacity under our unsecured senior line of credit equal to any outstanding notes issued under our commercial paper program. We use the net proceeds from the issuances of the notes for general working capital and other general corporate purposes. General corporate purposes may include, but are not limited to, the repayment of other debt and selective development, redevelopment, or acquisition of properties. As of December 31, 2021, we had $270.0 million of notes outstanding under our commercial paper program.

Interest expense

The following table summarizes interest expense for the years ended December 31, 2021, 2020, and 2019 (in thousands):

Year Ended December 31,
202120202019
Interest incurred$312,806$297,227$262,238
Capitalized interest(170,641)(125,618)(88,563)
Interest expense$142,165$171,609$173,675

F-44

11. ACCOUNTS PAYABLE, ACCRUED EXPENSES, AND OTHER LIABILITIES

The following table summarizes the components of accounts payable, accrued expenses, and other liabilities as of December 31, 2021 and 2020 (in thousands):

December 31,
20212020
Accounts payable and accrued expenses$513,416$285,021
Accrued construction438,866333,271
Acquired below-market leases341,585288,075
Conditional asset retirement obligations59,79747,070
Deferred rent liabilities12,3844,495
Operating lease liability434,745345,750
Unearned rent and tenant security deposits326,924276,751
Other liabilities82,69389,399
Total$2,210,410$1,669,832

As of December 31, 2021 and 2020, our conditional asset retirement obligations liability primarily consisted of the soil and groundwater remediation liabilities associated with certain of our properties. Some of our properties may contain asbestos or may be subjected to other hazardous or toxic substances, which, under certain conditions, requires remediation. We engage independent environmental consultants to conduct Phase I or similar environmental assessments at our properties. This type of assessment generally includes a site inspection, interviews, and a public records review, asbestos, lead-based paint and mold surveys, subsurface sampling, and other testing. We recognize a liability for the fair value of a conditional asset retirement obligation (including asbestos) when the fair value of the liability can be reasonably estimated. In addition, environmental laws and regulations subject our tenants, and potentially us, to liability that may result from our tenants’ routine handling of hazardous substances and wastes as part of their operations at our properties. These assessments and investigations of our properties have not to date revealed any additional environmental liability we believe would have a material adverse effect on our business and financial statements or that would require additional disclosures or recognition in our consolidated financial statements.

F-45

12. EARNINGS PER SHARE

From time to time, we enter into forward equity sales agreements, which are discussed in Note 15 – “Stockholders’ equity” to our consolidated financial statements. We consider the potential dilution resulting from the forward equity sales agreements on the EPS calculations. At inception, the agreements do not have an effect on the computation of basic EPS as no shares are delivered until settlement. The common shares issued upon the settlement of the forward equity sales agreements, weighted for the period these common shares were outstanding, are included in the denominator of basic EPS. To determine the dilution resulting from the forward equity sales agreements during the period of time prior to settlement, we calculate the number of weighted-average shares outstanding – diluted using the treasury stock method.

We account for unvested restricted stock awards that contain nonforfeitable rights to dividends as participating securities and include these securities in the computation of EPS using the two-class method. Our forward equity sales agreements are not participating securities and are therefore not included in the computation of EPS using the two-class method. Under the two-class method, we allocate net income (after amounts attributable to noncontrolling interests) to common stockholders and unvested restricted stock awards by using the weighted-average shares of each class outstanding for quarter-to-date and year-to-date periods independently, based on their respective participation rights to dividends declared (or accumulated) and undistributed earnings.

The table reconciles the numerators and denominators of the basic and diluted EPS computations for the years ended December 31, 2021, 2020, and 2019 (in thousands, except per share amounts):

Year Ended December 31,
202120202019
Net income$654,282$827,171$404,047
Net income attributable to noncontrolling interests(83,035)(56,212)(40,882)
Dividends on preferred stock——(3,204)
Preferred stock redemption charge——(2,580)
Net income attributable to unvested restricted stock awards(7,848)(10,168)(6,386)
Numerator for basic and diluted EPS – net income attributable to Alexandria Real Estate Equities, Inc.’s common stockholders$563,399$760,791$350,995
Denominator for basic EPS – weighted-average shares of common stock outstanding146,921126,106112,204
Dilutive effect of forward equity sales agreements539384320
Denominator for diluted EPS – weighted-average shares of common stock outstanding147,460126,490112,524
Net income per share attributable to Alexandria Real Estate Equities, Inc.’s common stockholders:
Basic$3.83$6.03$3.13
Diluted$3.82$6.01$3.12

F-46

13. INCOME TAXES

We have elected to be taxed as a REIT, under the Internal Revenue Code of 1986, as amended, (the “Code”). We believe we have qualified and continue to qualify as a REIT. Under the Code, a REIT that distributes at least 90% of its REIT taxable income to its shareholders annually and meets certain other conditions is not subject to federal income taxes, but could be subject to certain state, local, and foreign taxes. We distribute 100% of our taxable income annually; therefore, a provision for federal income taxes is not required.

We distributed all of our REIT taxable income in 2020 and 2019 and, as a result, did not incur federal income tax in those years on such income. For the year ended December 31, 2021, we expect to distribute all of our REIT taxable income and, as a result, do not expect to incur federal income tax. We expect to finalize our 2021 REIT taxable income when we file our 2021 federal income tax return in 2022.

The income tax treatment of distributions and dividends declared on our common stock and our Series D Convertible Preferred Stock for the years ended December 31, 2021, 2020, and 2019 was as follows (unaudited):

Common StockSeries D Convertible Preferred Stock(1)
Year Ended December 31,
2021202020192019
Ordinary income46.3%65.7%62.4%64.4%
Return of capital—13.23.2—
Capital gains at 25%3.8—2.22.2
Capital gains at 20%49.921.132.233.4
Total100.0%100.0%100.0%100.0%
Dividends declared$4.48$4.24$4.00$1.3125

(1)Refer to Note 15 – “Stockholders’ equity” to our consolidated financial statements for information regarding the conversion of our Series D Convertible Preferred Stock.

Beginning in 2018, the Tax Cuts and Jobs Act of 2017 added Section 199A to allow for a new tax deduction based on certain qualified business income. Section 199A provides eligible individual taxpayers a deduction of up to 20% of their qualified REIT dividends.

Our dividends declared in a given quarter are generally paid during the subsequent quarter. The taxability information presented above for our dividends paid in 2021 is based upon management’s estimate. Our federal tax return for 2021 is due on or before October 15, 2022, assuming we file for an extension of the due date. Our federal tax returns for previous tax years have not been examined by the IRS. Consequently, the taxability of distributions and dividends is subject to change.

In addition to our REIT tax returns, we file federal, state, and local tax returns for our subsidiaries. We file with jurisdictions located in the U.S., Canada, China, and other international locations and may be subject to audits, assessments, or other actions by local taxing authorities. We recognize tax benefits of uncertain tax positions only if it is more likely than not that the tax position will be sustained, based solely on its technical merits, with the taxing authority having full knowledge of all relevant information. The measurement of a tax benefit for an uncertain tax position that meets the “more likely than not” threshold is based on a cumulative probability model under which the largest amount of tax benefit recognized is the amount with a greater than 50% likelihood of being realized upon ultimate settlement with the taxing authority that has full knowledge of all relevant information.

As of December 31, 2021, there were no material unrecognized tax benefits. We do not anticipate a significant change to the total amount of unrecognized tax benefits within the next 12 months.

Interest expense and penalties, if any, are recognized in the first period during which the interest or penalties begin accruing, according to the provisions of the relevant tax law at the applicable statutory rate of interest. We did not incur any significant tax-related interest expense or penalties for the years ended December 31, 2021, 2020, and 2019.

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13. INCOME TAXES (continued)

The following reconciles net income (determined in accordance with GAAP) to taxable income as filed with the IRS for the years ended December 31, 2020 and 2019 (in thousands and unaudited):

Year Ended December 31,
20202019
Net income$827,171$404,047
Net income attributable to noncontrolling interests(56,212)(40,882)
Book/tax differences:
Rental revenue recognition(165,091)(132,979)
Depreciation and amortization220,046177,627
Share-based compensation30,69530,756
Interest expense(21,174)(13,687)
Sales of property(69,048)66,717
Impairments40,39812,334
Non-real estate investment income(377,820)(96,353)
Other22,3157,565
Taxable income before dividend deduction451,280415,145
Dividend deduction necessary to eliminate taxable income(1)(451,280)(415,145)
Estimated income subject to federal income tax$—$—

(1)Total common stock and preferred stock dividend distributions paid were approximately $533.0 million and $451.2 million during the years ended December 31, 2020 and 2019, respectively.

14. COMMITMENTS AND CONTINGENCIES

Employee retirement savings plan

We have a retirement savings plan pursuant to Section 401(k) of the Code whereby our employees may contribute a portion of their compensation to their respective retirement accounts in an amount not to exceed the maximum allowed under the Code. In addition to employee contributions, we have elected to provide company discretionary profit-sharing contributions (subject to statutory limitations), which amounted to approximately $5.0 million, $6.2 million, and $4.9 million for the years ended December 31, 2021, 2020, and 2019, respectively. Employees who participate in the plan are immediately vested in their contributions and in the contributions made on their behalf by the Company.

Concentration of credit risk

We maintain our cash and cash equivalents at insured financial institutions. The combined account balances at each institution periodically exceed the FDIC insurance coverage of $250,000, and, as a result, there is a concentration of credit risk related to amounts in excess of FDIC insurance coverage. We have not experienced any losses to date on our invested cash.

Our rental revenue is generated by a diverse array of many tenants. As of December 31, 2021, we had 1,201 leases with a total of 893 tenants. The inability of any single tenant to make its lease payments is unlikely to have a severe or financially disruptive effect on our operations. As of December 31, 2021, our three largest tenants accounted for 3.0%, 3.0%, and 2.3% of our aggregate annual rental revenue individually, or 8.3% in the aggregate.

Commitments

As of December 31, 2021, remaining aggregate costs under contract for the construction of properties undergoing development, redevelopment, and improvements under the terms of leases approximated $2.8 billion. We expect payments for these obligations to occur over one to three years, subject to capital planning adjustments from time to time. We may have the ability to cease the construction of certain properties, which would result in the reduction of our commitments. In addition, we have letters of credit and performance obligations aggregating $106.8 million primarily related to deposits for acquisitions in our Greater Boston and San Francisco Bay Area markets. We are committed to funding approximately $391.0 million related to our non-real estate investments. These funding commitments are primarily associated with our investments in privately held entities that report NAV, which expire at various dates over the next 11 years, with a weighted-average expiration of 9.0 years as of December 31, 2021.

F-48

15. STOCKHOLDERS’ EQUITY

Common equity transactions

During the year ended December 31, 2021, we completed issuances and executed forward equity sales agreements for an aggregate 20.8 million shares of common stock, including the exercise of underwriters’ option, for an aggregate net proceeds of approximately $3.5 billion, as follows:

  • In January 2021 and June 2021, we entered into forward equity sales agreements aggregating $1.1 billion and $1.5 billion, respectively, to sell an aggregate of 6.9 million and 8.1 million of our common stock, respectively, including the exercise of underwriters’ options, at pubic offering price of $164.00 and $184.00, respectively, before underwriting discounts and commissions. During 2021, we issued all 15.0 million shares under these forward equity sales agreements and received net proceeds of $2.5 billion.

  • In March 2021, we issued the remaining 362 thousand shares of common stock to settle our forward equity sales agreements that were outstanding as of December 31, 2020 and received net proceeds of $56.2 million.

  • In February 2021, we entered into a new ATM common stock offering program, which allowed us to sell up to an aggregate of $1.0 billion of our common stock.

  • We issued 5.5 million shares under our ATM program and received net proceeds of $984.6 million.

  • As of December 31, 2021, we have no amounts remaining under this ATM program.

  • In December 2021, we entered into a new ATM common stock offering program, which allows us to sell up to an aggregate of $1.0 billion of our common stock. As of December 31, 2021, the full amount remains available for future sales of our common stock.

In January 2022, we entered into forward equity sales agreements to sell 8.1 million shares of our common stock (including the exercise of underwriters’ option) aggregating $1.7 billion at a public offering price of $210.00 per share, before underwriting discounts and commissions.

7.00% Series D cumulative convertible preferred stock repurchases and conversion

As of December 31, 2021, 2020, and 2019, we had no outstanding shares of our Series D Convertible Preferred Stock. During the year ended December 31, 2019, we repurchased, in privately negotiated transactions, 275,000 outstanding shares of our Series D Convertible Preferred Stock at an aggregate price of $9.2 million, or $33.60 per share. We recognized a preferred stock redemption charge of $2.6 million during the year ended December 31, 2019, including the write-off of original issuance costs of approximately $215 thousand. In September 2019, we had elected to convert the remaining 2.3 million outstanding shares of our Series D Convertible Preferred Stock into shares of our common stock. The Series D Convertible Preferred Stock became eligible for mandatory conversion at our discretion, at a set conversion rate of 0.2513 shares of common stock to one share of preferred stock, upon our common stock price’s exceeding $149.46 per share for the specified period of time required to cause the mandatory conversion. In October 2019, we converted the Series D Convertible Preferred Stock into 578 thousand shares of common stock. This conversion was accounted for as an equity transaction, and we did not recognize a gain or loss.

Accumulated other comprehensive loss

The change in accumulated other comprehensive loss attributable to Alexandria Real Estate Equities, Inc.’s stockholders during the year ended December 31, 2021, was entirely due to net unrealized losses of $669 thousand on foreign currency translation related to our operations in Canada and China.

Common stock, preferred stock, and excess stock authorizations

Our charter authorizes the issuance of 200.0 million shares of common stock, of which 158.0 million shares were issued and outstanding as of December 31, 2021. Our charter also authorizes the issuance of up to 100.0 million shares of preferred stock, none of which were issued and outstanding as of December 31, 2021. In addition, 200.0 million shares of “excess stock” (as defined in our charter) are authorized, none of which were issued and outstanding as of December 31, 2021.

F-49

16. SHARE-BASED COMPENSATION

Stock plan

For the purpose of attracting and retaining the highest-quality personnel, providing for additional incentives, and promoting the success of our Company, we have historically issued two forms of share-based compensation under our equity incentive plan: (i) options to purchase common stock and (ii) restricted stock. We have not granted any options since 2002. Each restricted share issued reduced our share reserve by three shares (3:1 ratio) prior to March 23, 2018, and by one share (1:1 ratio) on and after March 23, 2018. As of December 31, 2021, there were 2,556,301 shares reserved for the granting of future options and stock awards under the equity incentive plan.

In addition, our stock plan permits us to issue share awards to our employees, non-employees, and non-employee directors. A share award is an award of common stock that (i) may be fully vested upon issuance or (ii) may be subject to the risk of forfeiture under Section 83 of the Code. Shares issued generally vest over a four-year period from the date of issuance, and the sale of the shares is restricted prior to the date of vesting. Certain time-based restricted share awards are also subject to an additional one-year holding period after vesting. The unearned portion of time-based share awards is amortized as stock compensation expense on a straight-line basis over the vesting period. Certain restricted share awards are subject to vesting based upon the satisfaction of levels of performance and market conditions. Failure to satisfy the threshold performance conditions will result in the forfeiture of shares. Forfeiture of share awards with time-based or performance-based restrictions results in a reversal of previously recognized share-based compensation expense. Forfeiture of share awards with market-based restrictions does not result in a reversal of previously recognized share-based compensation expense.

The following is a summary of the stock awards activity under our equity incentive plan and related information for the years ended December 31, 2021, 2020, and 2019:

Number of Share AwardsWeighted-Average Grant Date Fair Value Per Share
Outstanding at December 31, 20181,712,376$105.22
Granted768,625$134.70
Vested(666,836)$96.77
Forfeited(14,480)$119.88
Outstanding at December 31, 20191,799,685$119.59
Granted753,473$147.71
Vested(688,599)$115.57
Forfeited(39,279)$117.76
Outstanding at December 31, 20201,825,280$132.95
Granted740,920$174.32
Vested(709,737)$131.54
Forfeited(33,003)$99.55
Outstanding at December 31, 20211,823,460$150.89
Year Ended December 31,
(In thousands)202120202019
Total grant date fair value of stock awards vested$93,359$79,578$64,530
Total gross compensation recognized for stock awards$94,748$80,651$68,036
Capitalized stock compensation$46,079$37,149$24,396

Certain restricted stock awards granted during each year from 2018 to 2021 are subject to performance and market conditions. The grant date fair value of these awards is determined using a Monte Carlo simulation pricing model using the following assumptions for 2021, 2020, and 2019, respectively: (i) expected term of 3.0 years, 3.0 years, and 3.0 years (equal to the remaining performance measurement period at the grant date), (ii) volatility of 29.0%, 17.0%, and 18.0% (approximating a blended average of implied and historical volatilities), (iii) dividend yield of 2.8%, 2.8%, and 3.2%, and (iv) risk-free rate of 0.23%, 1.63%, and 2.60%.

As of December 31, 2021, there was $222.3 million of unrecognized compensation related to unvested share awards under the equity incentive plan, which is expected to be recognized over the next four years and has a weighted-average vesting period of approximately 19 months.

F-50

17. NONCONTROLLING INTERESTS

Noncontrolling interests represent the third-party interests in certain entities in which we have a controlling interest. These entities owned 54 properties as of December 31, 2021 and are included in our consolidated financial statements. Noncontrolling interests are adjusted for additional contributions and distributions, the proportionate share of the net earnings or losses, and other comprehensive income or loss. Distributions, profits, and losses related to these entities are allocated in accordance with the respective operating agreements. During the years ended December 31, 2021 and 2020, we distributed $112.4 million and $87.3 million, respectively, to our consolidated real estate joint venture partners.

Certain of our noncontrolling interests have the right to require us to redeem their ownership interests in the respective entities. We classify these ownership interests in the entities as redeemable noncontrolling interests outside of total equity in our consolidated balance sheets. Redeemable noncontrolling interests are adjusted for additional contributions and distributions, the proportionate share of the net earnings or losses, and other comprehensive income or loss. If the amount of a redeemable noncontrolling interest is less than the maximum redemption value at the balance sheet date, such amount is adjusted to the maximum redemption value. Subsequent declines in the redemption value are recognized only to the extent that previous increases have been recognized.

Refer to the “Formation of consolidated real estate joint ventures and sales of partial interest” section in Note 4 – “Consolidated and unconsolidated real estate joint ventures” to our consolidated financial statements for additional information.

18. ASSETS CLASSIFIED AS HELD FOR SALE

As of December 31, 2021, one property aggregating 334,144 RSF was classified as held for sale in our consolidated financial statements. We ceased depreciation of this property upon its classification as held for sale. This property did not meet the criteria for classification as a discontinued operation.

Upon classification of an asset as held for sale, we recognize an impairment charge if the carrying amount of the long-lived asset exceeds its fair value less cost to sell. Subsequently, as a result of our quarterly assessment, we recognize an incremental impairment charge for any decrease in the asset’s fair value less cost to sell. Conversely, a gain is recognized for a subsequent increase in fair value less cost to sell, limited to the cumulative net loss previously recognized. Refer to the “Impairment of long-lived assets” section within Note 2 – “Summary of significant account policies” and the “Sales of real estate assets and impairment charges” section within Note 3 – “Investments in real estate” to our consolidated financial statements for information about impairment charges related to our assets held for sale recognized during the year ended December 31, 2021.

The following is a summary of net assets as of December 31, 2021 and 2020 for our real estate investments that were classified as held for sale as of each respective date (in thousands):

December 31,
20212020
Total assets$17,749$117,879
Total liabilities(1,083)(33,081)
Total accumulated other comprehensive loss(1,750)(841)
Net assets classified as held for sale$14,916$83,957

19. SUBSEQUENT EVENTS

For transactions completed in January 2022, refer to the following notes to our consolidated financial statements:

  • For completed acquisitions, refer to the “Acquisitions” section in Note 3 – “Investments in real estate.”

  • For the formation of consolidated joint ventures, refer to Note 4 – “Consolidated and unconsolidated real estate joint ventures.”

  • For equity transactions, refer to the “Common equity transactions” section of Note 15 – “Stockholders’ equity.”

F-51

SCHEDULE III

Alexandria Real Estate Equities, Inc. and Subsidiaries

Schedule III

Consolidated Financial Statement Schedule of Real Estate and Accumulated Depreciation

December 31, 2021

(Dollars in thousands)

Initial CostsCosts Capitalized Subsequent to AcquisitionsTotal Costs
PropertyMarketEncumbrancesLandBuildings & ImprovementsBuildings & ImprovementsLandBuildings & ImprovementsTotal(1)Accumulated Depreciation(2)Net Cost BasisDate of Construction(3)Date Acquired
Alexandria Center® at Kendall SquareGreater Boston$—$511,875$822,706$1,470,329$511,875$2,293,035$2,804,910$(362,489)$2,442,4211995 - 20172005 - 2021
Alexandria Center® at One Kendall SquareGreater Boston196,529349,952483,816509,540349,952993,3561,343,308(143,728)1,199,5801985 - 20192016 - 2017
Alexandria Technology Square®Greater Boston——619,658277,958—897,616897,616(306,522)591,0942001 - 20122006
The Arsenal on the CharlesGreater Boston—191,797354,611221,488191,797576,099767,896(16,705)751,1912000 - 20212019 - 2021
480 Arsenal Way and 500 and 550 Arsenal StreetGreater Boston—104,62821,623106,026104,628127,649232,277(48,239)184,0382001 - 20092000 - 2021
640 Memorial DriveGreater Boston——174,8781,390—176,268176,268(51,565)124,70320112015
780 and 790 Memorial DriveGreater Boston———55,236—55,23655,236(27,307)27,92920022001
167 Sidney Street and 99 Erie StreetGreater Boston——12,61313,909—26,52226,522(8,783)17,7392006 - 20122005 - 2006
79/96 13th Street (Charlestown Navy Yard)Greater Boston——6,2478,762—15,00915,009(6,817)8,19220121998
Alexandria Center® for Life Science – FenwayGreater Boston—912,016617,552164,634912,016782,1861,694,202(11,927)1,682,27520192021
380 and 420 E StreetGreater Boston—156,3559,2297,418156,35516,647173,002(1,556)171,44620132020
5, 10, and 15 Necco StreetGreater Boston—277,55455,89773,345277,554129,242406,796(3,442)403,35420192019
99 A StreetGreater Boston—31,67187815,48031,67116,35848,029(938)47,09119682018
One Upland Road, 100 Tech Drive, and One Investors WayGreater Boston—67,329301,0003,54167,329304,541371,870(16,100)355,7701999 - 20152018 - 2021
Reservoir WoodsGreater Boston—88,840214,03811,44088,840225,478314,318(7,139)307,1792009 - 20102020
275 Grove StreetGreater Boston—70,476150,15914,05270,476164,211234,687(6,713)227,97420002020
Alexandria Park at 128Greater Boston—10,43941,59682,09710,439123,693134,132(52,060)82,0721997 - 20101998 - 2008
225, 266, and 275 Second AvenueGreater Boston—17,08669,99484,47517,086154,469171,555(34,655)136,9002014 - 20182014 - 2017
19 Presidential WayGreater Boston—12,83327,33325,23012,83352,56365,396(23,044)42,35219992005
840 Winter StreetGreater Boston—12,47044,39523,29012,47067,68580,155(1,362)78,79319992021
100 Beaver StreetGreater Boston—1,4669,04626,7361,46635,78237,248(10,453)26,79520062005
285 Bear Hill RoadGreater Boston—4223,5387,09442210,63211,054(2,926)8,12820132011
111 and 130 Forbes BoulevardGreater Boston—3,14615,7254,5743,14620,29923,445(7,296)16,14920062006 - 2007
20 Walkup DriveGreater Boston—2,2617,0999,0292,26116,12818,389(4,710)13,67920122006
OtherGreater Boston7,99192,156137,83146,09992,156183,930276,086(144)275,942VariousVarious
Alexandria Center® for Science and Technology – Mission BaySan Francisco—211,450210,211493,396211,450703,607915,057(184,410)730,6472007 - 20142004 - 2017
Alexandria Technology Center® – GatewaySan Francisco$—$193,004$364,078$303,215$193,004$667,293$860,297$(106,956)$753,3411984 - 20212002 - 2020

F-52

SCHEDULE III (continued)

Initial CostsCosts Capitalized Subsequent to AcquisitionsTotal Costs
PropertyMarketEncumbrancesLandBuildings & ImprovementsBuildings & ImprovementsLandBuildings & ImprovementsTotal(1)Accumulated Depreciation(2)Net Cost BasisDate of Construction(3)Date Acquired
213, 249, 259, 269, and 279 East Grand AvenueSan Francisco$—$59,199$—$545,037$59,199$545,037$604,236$(91,206)$513,0302008 - 20192004
Alexandria Center® for Life Science – South San FranciscoSan Francisco—32,2451,287458,83332,245460,120492,365(71,668)420,69720122002 - 2017
1122 and 1178 El Camino RealSan Francisco—231,7075,2244,370231,7079,594241,301(3)241,2981971 - 19722021
500 Forbes BoulevardSan Francisco—35,59669,09117,50335,59686,594122,190(31,522)90,66820012007
7000 Shoreline CourtSan Francisco—7,03839,70427,9937,03867,69774,735(24,327)50,40820012004
341 and 343 Oyster Point BoulevardSan Francisco—7,038—44,1897,03844,18951,227(21,280)29,9472009 - 20132000
849/863 Mitten Road/866 Malcolm RoadSan Francisco—3,2118,66530,1623,21138,82742,038(15,731)26,30720121998
Alexandria Center® for Life Science – San CarlosSan Francisco—433,63428,323601,498433,634629,8211,063,455(15,576)1,047,8791970 - 20212017 - 2021
3825 and 3875 Fabian WaySan Francisco—194,42454,5193,007194,42457,526251,950(6,175)245,7751969 - 20142019
Alexandria Stanford Life Science DistrictSan Francisco——260,93179,029—339,960339,960(22,084)317,8761998 - 20192003 - 2020
3330, 3412, 3420, 3440, 3450, and 3460 Hillview AvenueSan Francisco——332,2579,730—341,987341,987(7,873)334,1141978 - 20182020 - 2021
Alexandria PARCSan Francisco—72,85953,30928,97272,85982,281155,140(9,575)145,5651984 - 20192018
2475 and 2625/2627/2631 Hanover StreetSan Francisco——103,00512,661—115,666115,666(13,257)102,4092000 - 20031999 - 2021
2425 Garcia Avenue/2400/2450 Bayshore ParkwaySan Francisco6781,51221,32326,2611,51247,58449,096(25,242)23,85420081999
Shoreway Science CenterSan Francisco—20,04948,55425220,04948,80668,855(3,828)65,02720162019
1450 Page Mill RoadSan Francisco——84,467110—84,57784,577(9,908)74,66920172017
3350 West Bayshore RoadSan Francisco—4,8006,69338,4944,80045,18749,987(7,956)42,03119822005
901 California AvenueSan Francisco———3,797—3,7973,797—3,797N/A2021
88 Bluxome StreetSan Francisco—148,55121,514153,615148,551175,129323,680(23,098)300,582N/A2017
OtherSan Francisco—32,1118,34585,10432,11193,449125,560(5,989)119,571VariousVarious
Alexandria Center® for Life Science – New York CityNew York City———1,007,571—1,007,5711,007,571(229,709)777,8622010 - 20162006
219 East 42nd StreetNew York City—141,26663,3123,363141,26666,675207,941(31,730)176,21119952018
Alexandria Center® for Life Science – Long Island CityNew York City—47,74653,093112,85547,746165,948213,694(2,213)211,4811926 - 19422018 - 2019
One Alexandria SquareSan Diego—247,423192,755500,972247,423693,727941,150(207,633)733,5171980 - 20211994 - 2021
ARE Torrey RidgeSan Diego—22,124152,84083,74122,124236,581258,705(52,130)206,5752004 - 20212016
ARE NautilusSan Diego—6,68427,600124,7056,684152,305158,989(61,040)97,9492009 - 20121994 - 1997
Alexandria PointSan Diego—88,016393,713482,84188,016876,554964,570(159,767)804,8031988 - 20192010 - 2019
5200 Illumina WaySan Diego—38,34096,606196,91538,340293,521331,861(65,439)266,4222004 - 20172010
University DistrictSan Diego—61,75349,692219,05961,753268,751330,504(104,500)226,0041989 - 20181998 - 2020
SD Tech by AlexandriaSan Diego$—$81,428$254,069$192,032$81,428$446,101$527,529$(17,119)$510,4101988 - 20152013 - 2020

F-53

SCHEDULE III (continued)

Initial CostsCosts Capitalized Subsequent to AcquisitionsTotal Costs
PropertyMarketEncumbrancesLandBuildings & ImprovementsBuildings & ImprovementsLandBuildings & ImprovementsTotal(1)Accumulated Depreciation(2)Net Cost BasisDate of Construction(3)Date Acquired
Sequence District by AlexandriaSan Diego$—$163,610$281,389$9,270$163,610$290,659$454,269$(4,941)$449,3281997 - 20002020 - 2021
Pacific Technology ParkSan Diego—96,79666,66022,11296,79688,772185,568(1,205)184,3631989 - 19912021
Summers Ridge Science ParkSan Diego—21,154102,0463,68521,154105,731126,885(11,016)115,86920052018
ARE PortolaSan Diego—6,99125,15340,0386,99165,19172,182(18,338)53,8442005 - 20122007
7330 and 7360 Carroll RoadSan Diego—4,67424,0122,1254,67426,13730,811(9,978)20,8331983 - 20072010 - 2021
5810/5820 Nancy Ridge DriveSan Diego—3,49218,28532,7503,49251,03554,527(11,990)42,53720212004
9877 Waples StreetSan Diego—5,09211,90812,0805,09223,98829,080(1,180)27,90020202020
5871 Oberlin DriveSan Diego—1,3498,01620,3201,34928,33629,685(3,103)26,58220212010
3911, 3931, 3985, 4025, 4031, 4045, and 4075 Sorrento Valley BoulevardSan Diego—18,17742,72328,58418,17771,30789,484(37,143)52,3412007 - 20152010 - 2019
11025, 11035, 11045, 11055, 11065, and 11075 Roselle StreetSan Diego—4,15611,57146,2474,15657,81861,974(16,879)45,0952006 - 20141997 - 2014
OtherSan Diego—117,866155,80379,722117,866235,525353,391(28,341)325,050VariousVarious
The Eastlake Life Science Campus by AlexandriaSeattle—51,75083,012707,18351,750790,195841,945(175,538)666,4071997 - 20212002 - 2020
Alexandria Center® at South Lake UnionSeattle—76,0701,128288,91776,070290,045366,115(38,986)327,1291984 - 20172007 - 2019
219 Terry Avenue NorthSeattle—1,8192,30220,1661,81922,46824,287(8,686)15,60120122007
830 4th Avenue SouthSeattle—6,50012,0621,6566,50013,71820,218(358)19,86019952020
3000/3018 Western AvenueSeattle—1,4327,49724,5831,43232,08033,512(22,314)11,19820001998
410 West Harrison Street and 410 Elliott Avenue WestSeattle—3,8571,98917,5593,85719,54823,405(6,765)16,6402006 - 20082004
1010 4th AvenueSeattle—46,200—5,19546,2005,19551,395—51,395N/A2020
OtherSeattle—245,754224,60018,153245,754242,753488,507(4,120)484,387VariousVarious
Alexandria Center® for Life Science – Shady GroveMaryland—88,157261,626311,68688,157573,312661,469(113,427)548,0421985 - 20212004 - 2021
1330 Piccard DriveMaryland—2,80011,53336,3022,80047,83550,635(22,015)28,62020051997
1405 and 1450 Research BoulevardMaryland—2,78824,50710,9882,78835,49538,283(17,324)20,9591980 - 20061997 - 2021
1500 and 1550 East Gude DriveMaryland—1,5237,73110,4851,52318,21619,739(10,247)9,4921995 - 20031997
5 Research PlaceMaryland—1,4665,70830,7061,46636,41437,880(17,079)20,80120102001
5 Research CourtMaryland—1,64713,25824,0991,64737,35739,004(16,591)22,41320072004
12301 Parklawn DriveMaryland—1,4767,2671,6971,4768,96410,440(3,388)7,05220072004
Alexandria Technology Center® – Gaithersburg IMaryland—20,980121,95249,52520,980171,477192,457(49,941)142,5161992 - 20191997 - 2019
Alexandria Technology Center® – Gaithersburg IIMaryland—17,13467,825101,01617,134168,841185,975(36,064)149,9112000 - 20211997 - 2020
20400 Century BoulevardMaryland—3,6414,7597,8173,64112,57616,217—16,21720172021
401 Professional DriveMaryland—1,1296,94111,1301,12918,07119,200(8,602)10,59820071996
950 Wind River LaneMaryland$—$2,400$10,620$1,050$2,400$11,670$14,070$(3,919)$10,15120092010

F-54

SCHEDULE III (continued)

Initial CostsCosts Capitalized Subsequent to AcquisitionsTotal Costs
PropertyMarketEncumbrancesLandBuildings & ImprovementsBuildings & ImprovementsLandBuildings & ImprovementsTotal(1)Accumulated Depreciation(2)Net Cost BasisDate of Construction(3)Date Acquired
620 Professional DriveMaryland$—$784$4,705$8,235$784$12,940$13,724$(7,165)$6,55920122005
8000/9000/10000 Virginia Manor RoadMaryland——13,67910,238—23,91723,917(11,662)12,25520031998
14225 Newbrook DriveMaryland—4,80027,63922,5354,80050,17454,974(19,918)35,05620061997
Alexandria Center® for Life Science – DurhamResearch Triangle—90,686471,263128,94990,686600,212690,898(14,556)676,3421985 - 20212020 - 2021
Alexandria Center® for Advanced TechnologiesResearch Triangle—27,78416,958138,53227,784155,490183,274(14,375)168,8992007 - 20122012 - 2021
Alexandria Center® for AgTechResearch Triangle—2,8016,756180,8812,801187,637190,438(9,807)180,63120182017 - 2018
Alexandria Technology Center® – AlstonResearch Triangle—1,43017,48232,6621,43050,14451,574(26,489)25,0851985 - 20091998
108/110/112/114 TW Alexander DriveResearch Triangle——37644,943—45,31945,319(22,969)22,35020001999
Alexandria Innovation Center® – Research TriangleResearch Triangle—1,06521,21830,5831,06551,80152,866(22,564)30,3022005 - 20082000
7 Triangle DriveResearch Triangle—701—32,61270132,61233,313(9,084)24,22920112005
2525 East NC Highway 54Research Triangle—71312,82720,70071333,52734,240(13,280)20,96019952004
407 Davis DriveResearch Triangle—1,22917,7331,0281,22918,76119,990(4,609)15,38119982013
601 Keystone Park DriveResearch Triangle—78511,5467,31478518,86019,645(7,211)12,43420092006
6040 George Watts Hill DriveResearch Triangle———27,900—27,90027,900(4,725)23,17520152014
5 Triangle DriveResearch Triangle—1613,40912,67816116,08716,248(7,230)9,01819811998
6101 Quadrangle DriveResearch Triangle—9513,98211,41995115,40116,352(4,161)12,19120122008
Alexandria Center® for NextGen MedicinesResearch Triangle—94,184—1,87294,1841,87296,056—96,056N/A2021
CanadaCanada—22,80199,69315,41022,801115,103137,904(29,408)108,4961998 - 20202005 - 2021
VariousVarious—200,590265,065237,136200,590502,201702,791(52,503)650,288VariousVarious
Total – North America205,1986,811,3259,824,85612,096,9276,811,32521,921,78328,733,108(3,766,758)24,966,350
Asia———18,802—18,80218,802(4,483)14,31920152008
$205,198$6,811,325$9,824,856$12,115,729$6,811,325$21,940,585$28,751,910$(3,771,241)$24,980,669

F-55

SCHEDULE III (continued)

Alexandria Real Estate Equities, Inc.

Consolidated Financial Statement Schedule of Rental Properties and Accumulated Depreciation

December 31, 2021

(Dollars in thousands)

(1)As of December 31, 2021, the total cost of our real estate assets aggregated $28.8 billion, which was less than the cost of real estate for federal income tax purposes aggregating $29.3 billion by approximately $578.4 million.

(2)The depreciable life ranges up to 40 years for buildings and improvements, up to 20 years for land improvements, and the term of the respective lease for tenant improvements.

(3)Represents the later of the date of original construction or the date of the latest renovation.

F-56

SCHEDULE III (continued)

Alexandria Real Estate Equities, Inc.

Consolidated Financial Statement Schedule of Real Estate and Accumulated Depreciation

December 31, 2021

(In thousands)

A summary of activity of consolidated investments in real estate and accumulated depreciation is as follows:

December 31,
Real Estate202120202019
Balance at beginning of period$21,274,810$17,552,956$14,181,780
Acquisitions (including real estate, land, and joint venture consolidation)5,405,5692,825,5372,240,376
Additions to real estate2,267,8481,505,1521,143,035
Deductions (including dispositions and direct financing leases)(196,317)(608,835)(12,235)
Balance at end of period$28,751,910$21,274,810$17,552,956
December 31,
Accumulated Depreciation202120202019
Balance at beginning of period$3,182,438$2,708,918$2,268,087
Depreciation expense on properties607,927530,226448,661
Sale of properties(19,124)(56,706)(7,830)
Balance at end of period$3,771,241$3,182,438$2,708,918

F-57

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