| 10.65 | | | Form of 2020 Restricted Stock Unit Award Agreement (earnings per share), incorporated by reference to Exhibit 10.68 to the Company's Annual Report on Form 10-K for the year ended December 31, 2019 (File No. 001-34774) filed on February 22, 2020.* |
| 10.66 | | | Form of 2020 Restricted Stock Unit Award Agreement (3 Year Cliff Vest), incorporated by reference to Exhibit 10.69 to the Company's Annual Report on Form 10-K for the year ended December 31, 2019 (File No. 001-34774) filed on February 22, 2020.* |
| 10.67 | | | Form of 2021 Edward Tilly Restricted Stock Unit Award Agreement (relative total shareholder return) (filed herewith).* |
| 10.68 | | | Form of 2021 Edward Tilly Restricted Stock Unit Award Agreement (earnings per share) (filed herewith).* |
| 10.69 | | | Form of 2021 Restricted Stock Unit Award Agreement (for Executive Officers) (filed herewith).* |
| 10.70 | | | Form of 2021 Restricted Stock Unit Award Agreement (relative total shareholder return) (filed herewith).* |
| 10.71 | | | Form of 2021 Restricted Stock Unit Award Agreement (earnings per share) (filed herewith).* |
| 21.1 | | | Subsidiaries of Cboe Global Markets, Inc. (filed herewith). |
| 23.1 | | | Consent of Independent Registered Public Accounting Firm (filed herewith). |
| 23.2 | | | Consent of Independent Registered Public Accounting Firm (filed herewith). |
| 24.1 | | | Powers of Attorney (incorporated by reference to the signature page of this Annual Report on Form 10-K). |
| 31.1 | | | Certification of Chief Executive Officer pursuant to Rule 13a-14 (filed herewith). |
| 31.2 | | | Certification of Chief Financial Officer pursuant to Rule 13a-14 (filed herewith). |
| 32.1 | | | Certificate of Chief Executive Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (filed herewith). |
| 32.2 | | | Certificate of Chief Financial Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (filed herewith). |
| 101.INS | | | iXBRL Instance Document (filed herewith). |
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| 101.SCH | | | iXBRL Taxonomy Extension Schema Document (filed herewith). |
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| 101.CAL | | | iXBRL Taxonomy Extension Calculation Linkbase Document (filed herewith). |
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| 101.DEF | | | iXBRL Taxonomy Extension Definition Linkbase (filed herewith). |
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| 101.LAB | | | iXBRL Taxonomy Extension Label Linkbase Document (filed herewith). |
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| 101.PRE | | | iXBRL Taxonomy Extension Presentation Linkbase Document (filed herewith). |
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| 104 | | | Cover Page Interactive Data File (embedded as Inline XBRL document). |
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