| 10.80 | | | Form of 2022 Restricted Stock Unit Award Agreement for David Howson, incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on March 10, 2022.* |
| 10.81 | | | Form of 2023 Edward Tilly Restricted Stock Unit Award Agreement (relative total shareholder return), incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on February 14, 2023.* |
| 10.82 | | | Form of 2023 Edward Tilly Restricted Stock Unit Award Agreement (earnings per share), incorporated by reference to Exhibit 10.3 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on February 14, 2023.* |
| 10.83 | | | Form of 2023 Restricted Stock Unit Award Agreement (for Executive Officers) (filed herewith).* |
| 10.84 | | | Form of 2023 Restricted Stock Unit Award Agreement (relative total shareholder return) (filed herewith).* |
| 10.85 | | | Form of 2023 Restricted Stock Unit Award Agreement (earnings per share) (filed herewith).* |
| 10.86 | | | Form of 2023 Restricted Stock Unit Award Agreement without Retirement Vesting (relative total shareholder return) (filed herewith).* |
| 10.87 | | | Form of 2023 Restricted Stock Unit Award Agreement without Retirement Vesting (earnings per share) (filed herewith).* |
| 21.1 | | | Subsidiaries of Cboe Global Markets, Inc. (filed herewith). |
| 23.1 | | | Consent of Independent Registered Public Accounting Firm (filed herewith). |
| 24.1 | | | Powers of Attorney (incorporated by reference to the signature page of this Annual Report on Form 10-K). |
| 31.1 | | | Certification of Chief Executive Officer pursuant to Rule 13a-14 (filed herewith). |
| 31.2 | | | Certification of Chief Financial Officer pursuant to Rule 13a-14 (filed herewith). |
| 32.1 | | | Certificate of Chief Executive Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (filed herewith). |
| 32.2 | | | Certificate of Chief Financial Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (filed herewith). |
| 101.INS | | | iXBRL Instance Document (filed herewith). |
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| 101.SCH | | | iXBRL Taxonomy Extension Schema Document (filed herewith). |
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| 101.CAL | | | iXBRL Taxonomy Extension Calculation Linkbase Document (filed herewith). |
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| 101.DEF | | | iXBRL Taxonomy Extension Definition Linkbase (filed herewith). |
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| 101.LAB | | | iXBRL Taxonomy Extension Label Linkbase Document (filed herewith). |
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| 101.PRE | | | iXBRL Taxonomy Extension Presentation Linkbase Document (filed herewith). |
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| 104 | | | Cover Page Interactive Data File (embedded as Inline XBRL document). |
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