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| Exhibit No. | | Description |
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| 4.1 | | Officers’ Certificate, dated as of March 16, 2022, establishing the 3.000% Senior Notes due 2032 of Cboe Global Markets, Inc., incorporated by reference to Exhibit 4.2 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on March 16, 2022. |
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| 4.2 | | Form of 3.000% Senior Notes due 2032 (included in Exhibit 4.1 hereto). |
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| 10.1 | | Amendment No. 19 to the Restated License Agreement, dated November 1, 1994, by and between Standard & Poor’s Financial Services LLC (as successor-in-interest to Standard & Poor’s, a division of McGraw-Hill, Inc.) and Cboe Exchange, Inc. (f/k/a Chicago Board Options Exchange, Incorporated), effective as of February 23, 2022 (Filed herewith). |
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| 10.2 | | Second Amended and Restated Credit Agreement, dated as of February 25, 2022, by and among Cboe Global Markets, Inc., with Bank of America, N.A., as administrative agent and as swing line lender, certain lenders named therein, BofA Securities, Inc., as sole lead arranger and sole bookrunner and certain syndication agents named therein, incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on February 28, 2022. |
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| 10.3 | | Form of 2022 Restricted Stock Unit Award Agreement for David Howson, incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on March 10, 2022.* |
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| 10.4 | | Amendment No. 3 to Term Loan Credit Agreement, dated as of March 29, 2022, by and among Cboe Global Markets, Inc., Bank of America, N.A., as administrative agent and initial lender, incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-34774) filed on April 1, 2022. |
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| 31.1 | | Certification of Chief Executive Officer pursuant to Rule 13a-14 (Filed herewith). |
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| 31.2 | | Certification of Chief Financial Officer pursuant to Rule 13a-14 (Filed herewith). |
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| 32.1 | | Certificate of Chief Executive Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (Filed herewith). |
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| 32.2 | | Certificate of Chief Financial Officer pursuant to Rule 13a-14(b) and Section 1350 of Chapter 63 of Title 18 of the United States Code (Filed herewith). |
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| 101.INS | | XBRL Instance Document (Filed herewith). — The instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document. |
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| 101.SCH | | XBRL Taxonomy Extension Schema Document (Filed herewith). |
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| 101.CAL | | XBRL Taxonomy Extension Calculation Linkbase Document (Filed herewith). |
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| 101.DEF | | XBRL Taxonomy Extension Definition Linkbase (Filed herewith). |
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| 101.LAB | | XBRL Taxonomy Extension Label Linkbase Document (Filed herewith). |
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| 101.PRE | | XBRL Taxonomy Extension Presentation Linkbase Document (Filed herewith). |
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| 104 | | Cover Page Interactive Data File (embedded as Inline XBRL document). |
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