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Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

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Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

(a) Equity Compensation Plans

The following table summarizes share and exercise price information about our equity compensation plans as of December 31, 2022:

Plan CategoryNumber of Securities to Be Issued Upon Exercise of Outstanding Options, Warrants, and Rights**(1)**Weighted Average Exercise Price of Outstanding Options, Warrants, and RightsNumber of Securities Remaining Available for Future Issuance Under Equity Compensation Plans (Excluding Securities Reflected in the First Column) (2)
Equity compensation plans approved by security holders5,358,796$77.936,492,529
Equity compensation plans not approved by security holders———
Total5,358,796$77.936,492,529

(1) Includes 5,358,796 stock options remaining outstanding for future exercise.

(2)Includes 2,114,989 shares available for issuance under our Employee Stock Purchase Plan and 4,377,540 shares that may become subject to future awards in the form of stock options, restricted stock units, performance shares and performance-based restricted stock units under our 2022 Equity Incentive Plan.

(b) Security Ownership

The information contained under the heading “Security Ownership of Certain Beneficial Owners and Management” in the Proxy Statement is incorporated in this Form 10-K by reference.

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