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Item 15. (a)(3) and Item 15(b) Exhibits

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Item 15. (a)(3) and Item 15(b) Exhibits

We have identified below each management contract and compensation plan filed as an exhibit to this Annual Report on Form 10-K.

Exhibit No.DescriptionFiled with this Form 10-KIncorporation by Reference
FormFiling DateExhibit No.
2.1Agreement and Plan of Merger, dated as of February 17, 2021, by and among Charles River Laboratories International, Inc., Memphis Merger Sub, Inc., Cognate BioServices, Inc. and Mercury Fund 2 Holdco LLC, solely in its capacity as the initial representative of the Company Shareholders8-KFebruary 17, 20212.1
3.1Second Amended and Restated Certificate of Incorporation of Charles River Laboratories International, Inc. dated June 5, 2000S-1/AJune 23, 20003.1
3.2Sixth Amended and Restated By-Laws of Charles River Laboratories International, Inc.8-KDecember 15, 20213.1
4.1Form of Common Stock certificate, $0.01 par value, of Charles River Laboratories International, Inc.S-1/AJune 23, 20004.1
4.2Description of Securities10-KFebruary 11, 20204.2
4.3Charles River Laboratories International, Inc. Form of Performance Share Unit granted under the 2018 Incentive Plan10-QAugust 5, 202010.3
4.4Charles River Laboratories International, Inc. Indenture Agreement with MUFG Union Bank, N.A. as Trustee dated April 3, 20188-KApril 3, 20184.1
4.5Charles River Laboratories International, Inc. Second Supplemental Indenture, dates as of October 23, 2019, to the Indenture dated as of April 3, 20188-KOctober 23, 20194.1
4.6Form of Note for 4.250% Senior Notes due 20288-KOctober 23, 20194.2
4.7Indenture, dated as of March 23, 2021, between Charles River International, Inc. and U.S. Bank National Association, as trustee8-KMarch 23, 20214.1
4.8First Supplemental Indenture, dated as of March 23, 2021, by and among the Charles River Laboratories International, Inc., the Guarantors and U.S. Bank National Association, as trustee8-KMarch 23, 20214.2
4.9Form of Note for 3.750% Senior Notes due 2029 (included with Exhibit 4.12)8-KMarch 23, 20214.3
4.10Form of Note for 4.000% Senior Notes due 2030 (included with Exhibit 4.12)8-KMarch 23, 20214.4
4.11Form of Senior Debt Indenture between Charles River Laboratories International, Inc. and U.S. Bank National AssociationS-3May 4, 20214.1
4.12Form of Subordinated Debt Indenture between Charles River Laboratories International, Inc. and U.S. Bank National AssociationS-3May 4, 20214.2
10.1*Charles River Laboratories International, Inc. 2016 Incentive Plan10-QAugust 3, 201610.1
10.2*Charles River Laboratories International, Inc. Amended and Restated 2018 Incentive Plan, dated March 20, 2018, as amended and restated May 6, 202010-QMay 7, 202010.1
10.3*Charles River Laboratories International, Inc. Form of Stock Option granted under the 2016 Incentive Plan10-KFebruary 14, 201710.4
10.4*Charles River Laboratories International, Inc. Form of Restricted Stock Unit granted under the 2016 Incentive Plan10-KFebruary 14, 201710.7
10.5*Charles River Laboratories International, Inc. Form of Non-Qualified Stock Option granted under the 2018 Incentive Plan10-QAugust 5, 202010.1
10.6*Charles River Laboratories International, Inc. Form of Restricted Stock Unit granted under the 2018 Incentive Plan10-QAugust 5, 202010.2

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Exhibit No.DescriptionFiled with this Form 10-KIncorporation by Reference
FormFiling DateExhibit No.
10.7*Charles River Corporate Officer Separation Plan dated April 30, 201010-QAugust 3, 201010.1
10.8*Form of Change in Control Agreement10-KFebruary 23, 200910.7
10.9*Charles River Laboratories International, Inc. Non-Employee Directors Deferral Plan dated April 5, 201610-QMay 4, 201610.1
10.10*Charles River Laboratories, Inc. Executive Life Insurance/Supplemental Retirement Income Plan10-KMarch 9, 200510.23
10.11*Agreement between David Smith and Charles River Laboratories, Inc. effective October 26, 202010-QOctober 29, 202010.1
10.12*Amended and Restated Employment Agreement by and between James C. Foster and Charles River International, Inc., dated May 18, 20218-KMay 18, 202199.1
10.13*Executive Incentive Compensation Program effective January 1, 202110-QMay 4, 202110.2
10.14*Charles River Laboratories amended and restated Deferred Compensation Plan, as amended10-QMay 4, 202110.3
10.15Ninth Amended and Restated Credit Agreement, dated as of April 21, 2021, among Charles River Laboratories International, Inc., the Subsidiary Borrowers party thereto, the lenders party thereto, JPMorgan Chase Bank, N.A., as administrative agent, and the other agents party thereto8-KApril 23, 202110.1
10.16*Charles River Laboratories International, Inc. Restricted Stock Unit Award, dated December 25, 2021 granted to Joseph W. LaPlume8-KDecember 27, 202110.1
10.17*Charles River Laboratories International, Inc. Performance Share Unit Award, dated December 25, 2021 granted to Joseph W. LaPlume8-KDecember 27, 202110.2
10.18*†Agreement between David Ross Smith and Charles River Discovery Research Services UK Limited dated February 15, 2022X
21.1Subsidiaries of Charles River Laboratories International, Inc.X
23.1Consent of PricewaterhouseCoopers LLPX
31.1Rule 13a-14(a)/15d-14(a) Certification of Chief Executive OfficerX
31.2Rule 13a-14(a)/15d-14(a) Certification of Chief Financial OfficerX
32.1Section 1350 Certification of the Chief Executive Officer and Chief Financial OfficerX
101.INSeXtensible Business Reporting Language (XBRL) Instance DocumentX
101.SCHInline XBRL Taxonomy Extension SchemaX
101.CALInline XBRL Taxonomy Extension Calculation LinkbaseX
101.DEFInline XBRL Taxonomy Extension Definition LinkbaseX
101.LABInline XBRL Taxonomy Extension Labels LinkbaseX
101.PREInline XBRL Taxonomy Extension Presentation LinkbaseX
104Cover Page Interactive Data File (embedded within the Inline XBRL document)
* Management contract or compensatory plan, contract or arrangement.
† Certain information in this exhibit was omitted by means of redacting a portion of the text and replacing it with [***]

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