Item 2. PROPERTIES

Corporate Headquarters

We lease approximately 1.1 million square feet of office and laboratory space at our corporate headquarters in Boston,

Massachusetts in two buildings pursuant to two leases that we entered into in May 2011 and amended in August 2024 to,

among other terms, extend the lease termination dates from December 2028 to June 2044. We have the option to extend the

term of the leases for up to two additional ten-year periods.

Additional United States and Worldwide Locations

In addition to our corporate headquarters, we lease an aggregate of approximately 865,000 square feet of space globally.

This space includes logistical, laboratory, commercial and manufacturing operations, as well as laboratory and office space to

support our research and development organizations. We also own approximately 213,000 square feet at our continuous

manufacturing facility in Massachusetts. Additionally, we are constructing the second building of our Leiden Campus in

Massachusetts (“Leiden II”), which will include approximately 348,000 square feet of office and laboratory space. We expect

Leiden II to be operational in late 2026.