Item 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND

ISSUER PURCHASES OF EQUITY SECURITIES

Market Information

Our common stock is traded on The Nasdaq Global Select Market under the symbol “VRTX.”

Shareholders

As of February 6, 2026, there were 94 holders of record of our common stock.

Performance Graph

Our performance graph includes the NASDAQ Biotechnology Index, which we believe is a comparable index consisting

of companies with similar industry classifications, and which we plan to use in our future performance graphs.

5-year cum return.jpg

Dividends

We have never paid any cash dividends on our common stock, and we do not anticipate paying any in the foreseeable

future.

Issuer Repurchases of Equity Securities

In May 2025, our Board of Directors approved a share repurchase program (our “2025 Share Repurchase Program”),

pursuant to which we are authorized to repurchase up to $4.0 billion of our common stock. The 2025 Share Repurchase

Program does not have an expiration date and can be discontinued at any time.

The table set forth below shows repurchases of securities by us during the three months ended December 31, 2025 under

our 2025 Share Repurchase Program.


Period	Total Number of Shares Purchased	Average Price Paid per Share	Total Number of Shares Purchased as Part of Publicly Announced Programs (1)	Approximate Dollar Value of Shares that May Yet Be Purchased Under the Programs (1)
Oct. 1, 2025 to Oct. 31, 2025	256,788	$409.11	256,788	$3,381,462,793
Nov. 1, 2025 to Nov. 30, 2025	—	$—	—	$3,381,462,793
Dec. 1, 2025 to Dec. 31, 2025	—	$—	—	$3,381,462,793
Total	256,788	$409.11	256,788	$3,381,462,793

(1)Under our 2025 Share Repurchase Program, we are authorized to purchase shares from time to time through open market or privately

negotiated transactions. Such purchases may be made pursuant to Rule 10b5-1 plans or other means as determined by our management

and in accordance with the requirements of the Securities and Exchange Commission.